Datasets:

wanglab
/

bioreason-pro-v2

protein_id string	split string	go_mf list	go_mf_leaf string	go_mf_tier2 list	go_mf_tier3 list	go_mf_tier4 list	go_mf_tier4_leaf string	go_bp list	go_bp_leaf string	go_bp_tier2 list	go_bp_tier3 list	go_bp_tier4 list	go_cc list	go_cc_leaf string	go_cc_tier2 list	go_cc_tier3 list	go_cc_tier4 list	go_ids list	protein_id_v1 string	sequence_changed bool	go_pred string	go_pred_leaf string	structure_path string	protein_names string	protein_function string	organism string	length float64	subcellular_location string	sequence string	string_id string	interaction_partners list	interpro_ids list	interpro_location string	ppi_formatted string	interpro_formatted string	reasoning null	final_answer null	taxid float64	reviewed string	sequence_md5 string	ppi_partners list	features list	n_features int64	pdb_ids list	pdb_formatted string	comments list	uniprot_status string	scored_aspects list	excluded_reason string	absorbed_v1_accessions list	uniprot_release string	interpro_release string	string_release string	gaf_release string	obo_version string	test_quality_basis string	test_quality string
A0A009IHW8	train	[ "GO:0003674", "GO:0003824", "GO:0003953", "GO:0016787", "GO:0016798", "GO:0016799", "GO:0050135" ]	GO:0003953 NAD+ nucleosidase activity GO:0050135 NAD(P)+ nucleosidase activity	null	null	null		[ "GO:0006139", "GO:0006163", "GO:0006195", "GO:0006725", "GO:0006753", "GO:0006793", "GO:0006796", "GO:0006807", "GO:0008150", "GO:0008152", "GO:0009056", "GO:0009117", "GO:0009166", "GO:0009987", "GO:0019362", "GO:0019364", "GO:0019439", "GO:0019637", "GO:0019674", "GO:0019677"...	GO:0019677 NAD catabolic process	null	null	null	null		null	null	null	[ "GO:0003674", "GO:0003824", "GO:0003953", "GO:0006139", "GO:0006163", "GO:0006195", "GO:0006725", "GO:0006753", "GO:0006793", "GO:0006796", "GO:0006807", "GO:0008150", "GO:0008152", "GO:0009056", "GO:0009117", "GO:0009166", "GO:0009987", "GO:0016787", "GO:0016798", "GO:0016799"...	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds), GO:0003953 (NAD+ nucleosidase activity) Biological Process (BP): GO:00...	Molecular Function (MF): GO:0003953 (NAD+ nucleosidase activity) Biological Process (BP): GO:0019677 (NAD catabolic process) Cellular Component (CC): GO:0005634 (nucleus)	AF-A0A009IHW8-F1-model_v4.cif	2' cyclic ADP-D-ribose synthase AbTIR (2'cADPR synthase AbTIR) (EC 3.2.2.-) (NAD(+) hydrolase AbTIR) (EC 3.2.2.6) (TIR domain-containing protein in A.baumannii) (AbTIR)	NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed 2'cADPR (v-cADPR) (PubMed:29395922, PubMed:36048923). Cleaves NADP(+), but does not cyclize the product (PubMe...	Acinetobacter baumannii (strain 1295743)	269	null	MSLEQKKGADIISKILQIQNSIGKTTSPSTLKTKLSEISRKEQENARIQSKLSDLQKKKIDIDNKLLKEKQNLIKEEILERKKLEVLTKKQQKDEIEHQKKLKREIDAIKASTQYITDVSISSYNNTIPETEPEYDLFISHASEDKEDFVRPLAETLQQLGVNVWYDEFTLKVGDSLRQKIDSGLRNSKYGTVVLSTDFIKKDWTNYELDGLVAREMNGHKMILPIWHKITKNDVLDYSPNLADKVALNTSVNSIEEIAHQLADVILNR	null	null	[ "IPR035897", "IPR000157" ]	{"IPR035897": [80, 266], "IPR000157": [133, 266]}		- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [80-266] - IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [133-266]	null	null	1,310,613	Reviewed	550b1c7bad80ec161cd7bc17cb9cfa07	[]	[ { "acc": null, "desc": "2' cyclic ADP-D-ribose synthase AbTIR", "eco": null, "end": 269, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type"...	52	[ "7UWG", "7UXU", "8G83" ]	- 7UWG: X-ray, 2.16 A, chain A/B/C/D [134-267] - 7UXU: EM, 2.74 A, chain A/B/C/D [134-267] - 8G83: X-ray, 3.03 A, chain A/B [134-269]	[ { "text": "Reaction=NAD(+) = 2'cADPR + nicotinamide + H(+); Xref=Rhea:RHEA:75299, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:194248; Evidence={ECO:0000269\|PubMed:36048923}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75300; Evidence={ECO:0000269\|PubMed:36048923}; Reaction=NAD(...	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A021WW32	train	null		null	null	[ "GO:0003674", "GO:0003682", "GO:0005488" ]	GO:0003682 chromatin binding	[ "GO:0000070", "GO:0000278", "GO:0000280", "GO:0000819", "GO:0006996", "GO:0007049", "GO:0007059", "GO:0007062", "GO:0007064", "GO:0007275", "GO:0007399", "GO:0008150", "GO:0009893", "GO:0009987", "GO:0010468", "GO:0010604", "GO:0010628", "GO:0016043", "GO:0016322", "GO:0019222"...	GO:0007064 mitotic sister chromatid cohesion GO:0010628 positive regulation of gene expression GO:0016322 neuron remodeling GO:0070193 synaptonemal complex organization	null	null	null	[ "GO:0000228", "GO:0000775", "GO:0000785", "GO:0000792", "GO:0000793", "GO:0000794", "GO:0000795", "GO:0005575", "GO:0005622", "GO:0005634", "GO:0005694", "GO:0005700", "GO:0005705", "GO:0005721", "GO:0008278", "GO:0031974", "GO:0031981", "GO:0032991", "GO:0043226", "GO:0043227"...	GO:0000795 synaptonemal complex GO:0005705 polytene chromosome interband GO:0005721 pericentric heterochromatin GO:0008278 cohesin complex	null	null	null	[ "GO:0000070", "GO:0000228", "GO:0000278", "GO:0000280", "GO:0000775", "GO:0000785", "GO:0000792", "GO:0000793", "GO:0000794", "GO:0000795", "GO:0000819", "GO:0005575", "GO:0005622", "GO:0005634", "GO:0005694", "GO:0005700", "GO:0005705", "GO:0005721", "GO:0006996", "GO:0007049"...	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of bio...	Molecular Function (MF): GO:0003682 (chromatin binding), GO:0005515 (protein binding) Biological Process (BP): GO:0010628 (positive regulation of gene expression), GO:0007064 (mitotic sister chromatid cohesion), GO:0016322 (neuron remodeling), GO:0070193 (synaptonemal complex organization) Cellular Component (CC): GO:0...	AF-A0A021WW32-F1-model_v4.cif	Verthandi, isoform B	Not known	Drosophila melanogaster (Fruit fly)	633	Nucleus {ECO:0000256\|ARBA:ARBA00004123}.	MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVRIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIEAQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIRCSIPSNINDKIFDNDVLENIESLDPHSLDAHADMPGSRLDGDGFGDSFGQPALFEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMNEITLVQNEDEGFALAPLDV...	7227.FBpp0112469	[ "SMC3", "SA", "SMC1", "Nipped-B", "pds5", "Sse", "wapl", "SA-2", "Pc", "polo", "eco", "Mau2", "CTCF", "Parp", "Msh6", "CG11403", "glu", "Ctf4", "timeout", "rudhira", "elg1", "Wee1", "CG10336", "Myt1", "c(2)M", "PCNA", "mts", "MED30", "Sce", "alpha-Cat", "U...	[ "IPR006910", "IPR049589", "IPR039781" ]	{"IPR006910": [1, 103], "IPR049589": [327, 404], "IPR039781": [1, 530]}	- Structural maintenance of chromosomes protein - LD34181p - Nipped-B protein - Precocious dissociation of sisters 5, isoform A - separase - Protein wings apart-like - Stromalin-2 - Polycomb group protein Pc - Serine/threonine-protein kinase polo - N-acetyltransferase eco - MAU2 chromatid cohesion factor homolog - CTCF...	- IPR006910: Rad21/Rec8-like protein, N-terminal (domain) [1-103] - IPR049589: NXP-1, middle HEAT-repeat binding domain (domain) [327-404] - IPR039781: Rad21/Rec8-like protein (family) [1-530]	null	null	7,227	Unreviewed	16b968f7cd6a2de6c4e78de3a581a39c	[ { "accession": "Q9VXE9", "combined_score": 999, "name": "Structural maintenance of chromosomes protein" }, { "accession": "Q95RF8", "combined_score": 999, "name": "LD34181p" }, { "accession": "A4UZ37", "combined_score": 999, "name": "Nipped-B protein" }, { "access...	[ { "acc": null, "desc": "Rad21/Rec8-like protein N-terminal", "eco": [ "ECO:0000259" ], "end": 103, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "s...	60	null		null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A021WZA4	train	null		null	null	null		null		null	null	null	[ "GO:0005575", "GO:0005886", "GO:0016020", "GO:0071944", "GO:0110165" ]	GO:0005886 plasma membrane	null	null	null	[ "GO:0005575", "GO:0005886", "GO:0016020", "GO:0071944", "GO:0110165" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transpo...	Molecular Function (MF): GO:0022821 (solute:potassium antiporter activity), GO:0005432 (calcium:sodium antiporter activity) Biological Process (BP): GO:0070588 (calcium ion transmembrane transport), GO:0019722 (calcium-mediated signaling) Cellular Component (CC): GO:0005886 (plasma membrane)	AF-A0A021WZA4-F1-model_v4.cif	Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5)	Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.	Drosophila melanogaster (Fruit fly)	499	Golgi apparatus, trans-Golgi network membrane {ECO:0000256\|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256\|ARBA:ARBA00004166}. Melanosome {ECO:0000256\|ARBA:ARBA00004223}.	MKYINCTQPAIDDFPRDLFSEAQRQSGAVVLHVIASLYLFVALAVVCDEYFVPAVEKICAALNMSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTRDSIAYGVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQKCAKELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAVGLCSGPGAIVQMAPLDDAEAESHVAVAAADEGRKEEGYSLLSYPKDKSCFAQFTWLIIWPIHLLFRIAIPDCK...	7227.FBpp0290356	null	[ "IPR004481", "IPR004837", "IPR044880" ]	{"IPR004481": [5, 492], "IPR004837": [33, 480], "IPR044880": [64, 482]}		- IPR004481: Sodium/potassium/calcium exchanger (family) [5-492] - IPR004837: Sodium/calcium exchanger membrane region (domain) [33-480] - IPR044880: NCX, central ion-binding domain superfamily (homologous_superfamily) [64-482]	null	null	7,227	Unreviewed	6743e2e434a81034f3ce5b5b267ea000	[]	[ { "acc": null, "desc": "Helical", "eco": [ "ECO:0000256" ], "end": 51, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 29, "type": "TRAN...	54	null		[ { "text": "Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence={ECO:0000256\|ARBA:ARBA00033627};", "topic": "CATALYTIC ACTIVITY" }, { "text": "Belongs to the Ca(2+):cation antipo...	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FBW4	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019958" ]	GO:0019958 C-X-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019958" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019958 (C-X-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regu...	Molecular Function (MF): GO:0019958 (C-X-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900121 (negative...	AF-A0A023FBW4-F1-model_v4.cif	Evasin P1142	Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL10 and CXCL11.	Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)	97	Secreted {ECO:0000305}.	MTSHGAVKIAIFAVIALHSIFECLSKPQILQRTDHSTDSDWDPQMCPETCNPSKNISCSSECLCVTLGGGDETGTCFNMSGVDWLGHAQASDGHNDG	null	null	null	null			null	null	34,607	Reviewed	e8da69466c6b6352e15ce5604fa2e832	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 25, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	13	null		null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FBW7	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023FBW7-F1-model_v4.cif	Evasin P546	Salivary chemokine-binding protein which binds to host chemokines CCL1, CCL3, CCL5 and CCL22.	Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)	118	Secreted {ECO:0000305}.	MKVLLYIAASCLMLLALNVSAENTQQEEEDYDYGTDTCPFPVLANKTNKAKFVGCHQKCNGGDQKLTDGTACYVVERKVWDRMTPMLWYSCPLGECKNGVCEDLRKKEECRKGNGEEK	null	null	[ "IPR045797" ]	{"IPR045797": [38, 110]}		- IPR045797: Evasins Class A (family) [38-110]	null	null	34,607	Reviewed	a217d56db4c858535ca259005e70d259	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 21, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	17	null		null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FDY8	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023FDY8-F1-model_v4.cif	Evasin P974 (EVA-P974)	Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL1, CCL3, CCL4, CCL7, CCL8, CCL11, CCL13, CCL14, CCL16, CCL17, CCL18 and CCL22.	Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)	118	Secreted {ECO:0000305}.	MKVLLCIAASCLMLLALNVSAENTQQEEQDYDYGTDTCPFPVLANKTNKAKFVGCHQKCNGGDQKLTDGTACYVVERKVWDRMTPMLWYECPLGECKNGVCEDLRKKEDCRKGNGEEK	null	null	[ "IPR045797" ]	{"IPR045797": [38, 110]}		- IPR045797: Evasins Class A (family) [38-110]	null	null	34,607	Reviewed	3ae077f9b5bd2903e4f91b13808040ae	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 21, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	32	[ "7S4N", "7S58", "7S59", "7SO0" ]	- 7S4N: X-ray, 1.65 A, chain A/C [30-114] - 7S58: X-ray, 1.82 A, chain A/B/C/D [30-114] - 7S59: X-ray, 2.39 A, chain 1/3 [30-114] - 7SO0: X-ray, 1.74 A, chain A [30-114]	null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FF81	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019958" ]	GO:0019958 C-X-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019958" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019958 (C-X-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regu...	Molecular Function (MF): GO:0019958 (C-X-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900121 (negative...	AF-A0A023FF81-F1-model_v4.cif	Evasin P1126	Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL10 and CXCL11.	Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)	90	Secreted {ECO:0000305}.	MTSHSAVRIAIFAVIALHSIFECLSKPQILQRTDKSTDSEWDPQTCPETCIPSKNITCSDGCVCVKLGEEEEGTCFNMTGVDWLGSPSDD	null	null	null	null			null	null	34,607	Reviewed	ce89671846e313da4fd34a559e6d170c	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 25, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	13	null		null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FFB5	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023FFB5-F1-model_v4.cif	Evasin P983	Salivary chemokine-binding protein which binds to host chemokines CCL2, CCL3 and CCL8.	Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)	119	Secreted {ECO:0000305}.	MKASFCVIASCLVVFALKGTAEDTGTEDDFDYGNTGCPFPVLGNYKSNMTKPVGCKNKCGSGYEVLNDTTPCYVIDQKVFNNMVPLRQYSKCPLGFCENGECKPNDQAEDCYKGREEQK	null	null	[ "IPR045797" ]	{"IPR045797": [37, 111]}		- IPR045797: Evasins Class A (family) [37-111]	null	null	34,607	Reviewed	9f096f795ba577886e3dbe256afa9da9	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 21, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	18	null		[ { "text": "Sequence=JAC19634.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};", "topic": "SEQUENCE CAUTION" } ]	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FFD0	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		[ "GO:0008150", "GO:0009966", "GO:0009968", "GO:0010469", "GO:0010646", "GO:0010648", "GO:0023051", "GO:0023057", "GO:0030334", "GO:0030336", "GO:0032091", "GO:0032101", "GO:0032102", "GO:0040012", "GO:0040013", "GO:0043393", "GO:0044092", "GO:0048519", "GO:0048523", "GO:0048583"...	GO:1900137 negative regulation of chemokine activity	null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0008150", "GO:0009966", "GO:0009968", "GO:0010469", "GO:0010646", "GO:0010648", "GO:0019955", "GO:0019956", "GO:0019957", "GO:0023051", "GO:0023057", "GO:0030334", "GO:0030336", "GO:0032091", "GO:0032101", "GO:0032102", "GO:0040012"...	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023FFD0-F1-model_v4.cif	Evasin P991 (EVA-ACA1001)	Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL2, CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL6, CCL7, CCL8, CCL9, CCL11, CCL12, CCL13, CCL14, CCL16, CCL17, CCL18, CCL19, CCL22, CCL23, CCL24 and CCL27.	Amblyomma cajennense (Cayenne tick) (Acarus cajennensis)	136	Secreted {ECO:0000305}.	MHSTIVYACLLALAVFVALHGTPLAALAENGEGTTQPDYDNSTDYYNYEDFKCTCPAPHLNNTNGTVMKPIGCYYTCNVTRCTAPDTYPCYNLTEHQAKNLTTSPTTLCAVGNCDHGICVPNGTKELCFKAPNLEE	null	null	[ "IPR045797" ]	{"IPR045797": [55, 128]}		- IPR045797: Evasins Class A (family) [55-128]	null	null	34,607	Reviewed	7bc9f045e139c9910cdfbee93ae5d6b2	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 28, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	34	[ "8FK9" ]	- 8FK9: X-ray, 2.70 A, chain A/B [29-136]	null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023FT45	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023FT45-F1-model_v4.cif	Evasin P985	Salivary chemokine-binding protein which binds to host chemokine CCL5.	Amblyomma parvum (South American tick)	132	Secreted {ECO:0000305}.	MHSTIAYVSLLPLALFVAMHGASTDEESEELGASTDVDYEELDANCTCPAPALTSTRNNKHYPLGCIYNCSSYNCTIPDGTPCYVLTLGEVKEHLQIGSTVPNCTCGLCRNGTCVSNGTVEECFAVEEIEET	null	null	[ "IPR045797" ]	{"IPR045797": [48, 123]}		- IPR045797: Evasins Class A (family) [48-123]	null	null	251,391	Reviewed	4b3455e33d612567051000d6381cc845	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 24, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	22	null		null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023G6B6	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023G6B6-F1-model_v4.cif	Evasin P1180	Salivary chemokine-binding protein which binds to host chemokines CCL2, CCL3, CCL4, CCL8 and CCL18.	Amblyomma triste (Neotropical tick)	116	Secreted {ECO:0000305}.	MARNWSFRVIFVSAMWCALLKFATLEEPKDGYDYTEGCPFVVLGNGTHAKPAGCSHLCNGAPETLDDNMECYNVTEEVAKRMTPDIPYTCWLGWCSKGECKRDNRTEVCYRGSERE	null	null	[ "IPR045797" ]	{"IPR045797": [38, 109]}		- IPR045797: Evasins Class A (family) [38-109]	null	null	251,400	Reviewed	d14d378c8f4b9cade6840d96ab52451a	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 25, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	18	null		[ { "text": "Sequence=JAC29349.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};", "topic": "SEQUENCE CAUTION" } ]	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023G9N9	train	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	GO:0019957 C-C chemokine binding	null	null	null		null		null	null	null	null		null	null	null	[ "GO:0003674", "GO:0005488", "GO:0005515", "GO:0019955", "GO:0019956", "GO:0019957" ]	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regula...	Molecular Function (MF): GO:0019957 (C-C chemokine binding) Biological Process (BP): GO:0009968 (negative regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation...	AF-A0A023G9N9-F1-model_v4.cif	Evasin P1183	Salivary chemokine-binding protein which binds to host chemokine CCL2.	Amblyomma triste (Neotropical tick)	115	Secreted {ECO:0000305}.	MTRNWSFRVIFVSAMWCALLKFATLEAPKDDFEYDGGCPFVVLDNGTHVKPAGCSHLCNGAPETLDNIECYNVTEEVAKRMTPGIPYACWLGWCSKGECKRDNRTEVCYRGSEEE	null	null	[ "IPR045797" ]	{"IPR045797": [38, 108]}		- IPR045797: Evasins Class A (family) [38-108]	null	null	251,400	Reviewed	c23c5d0b151c9ca7783d966b595f95cf	[]	[ { "acc": null, "desc": null, "eco": [ "ECO:0000255" ], "end": 25, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 1, "type": "SIGNAL" ...	18	null		[ { "text": "Sequence=JAC29608.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};", "topic": "SEQUENCE CAUTION" } ]	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null
A0A023GPJ3	train	null		null	null	null		[ "GO:0002791", "GO:0002792", "GO:0008150", "GO:0010646", "GO:0010648", "GO:0010817", "GO:0023051", "GO:0023057", "GO:0032879", "GO:0046883", "GO:0046888", "GO:0048519", "GO:0048523", "GO:0050789", "GO:0050794", "GO:0051046", "GO:0051048", "GO:0051049", "GO:0051051", "GO:0065007"...	GO:0090278 negative regulation of peptide hormone secretion	null	null	null	[ "GO:0005575", "GO:0005622", "GO:0005737", "GO:0005829", "GO:0110165" ]	GO:0005829 cytosol	null	null	null	[ "GO:0002791", "GO:0002792", "GO:0005575", "GO:0005622", "GO:0005737", "GO:0005829", "GO:0008150", "GO:0010646", "GO:0010648", "GO:0010817", "GO:0023051", "GO:0023057", "GO:0032879", "GO:0046883", "GO:0046888", "GO:0048519", "GO:0048523", "GO:0050789", "GO:0050794", "GO:0051046"...	null	false	Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-str...	Molecular Function (MF): GO:0000976 (transcription cis-regulatory region binding) Biological Process (BP): GO:0090278 (negative regulation of peptide hormone secretion) Cellular Component (CC): GO:0005829 (cytosol)	AF-A0A023GPJ3-F1-model_v4.cif	Chronophage, isoform J	Not known	Drosophila melanogaster (Fruit fly)	1,140	Nucleus {ECO:0000256\|ARBA:ARBA00004123}.	MDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSPADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSP...	7227.FBpp0423187	[ "ken", "CG8042" ]	[ "IPR051497", "IPR013087", "IPR036236" ]	{"IPR051497": [52, 1063], "IPR013087": [195, 1043], "IPR036236": [643, 1033]}	- UBX domain-containing protein 4	- IPR051497: Developmental and Hematopoietic Transcription Factors (family) [52-1063] - IPR013087: Zinc finger C2H2-type (domain) [195-1043] - IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [643-1033]	null	null	7,227	Unreviewed	e03a4a38b4d6901eec11d475ce585289	[ { "accession": "Q9Y114", "combined_score": 757, "name": "UBX domain-containing protein 4" } ]	[ { "acc": null, "desc": "C2H2-type", "eco": [ "ECO:0000259" ], "end": 671, "end_unknown": null, "member_acc": null, "member_db": null, "pair": null, "parent_acc": null, "representative": null, "residue": null, "src": "uniprot", "start": 644, "type": "...	90	null		null	live	null	null	null	2026_02	109.0	v12.5	235	releases/2023-01-01	null	null

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`proteins_extra_preds` — GO-GPT predictions for `proteins_extra`

One row per protein of proteins_extra, same splits (train, test, ground, drop), same row order, joinable on protein_id. Columns:

column	meaning
`protein_id`	UniProt accession, as in `proteins_extra`
`gogpt_seen_in_train`	the protein contributed at least one training example to the GO-GPT run — its predictions are memorised, not generalised. `train`-split proteins without any in-vocabulary tier-1∪2 label never produced an example and are `false`
`gogpt_in_val`	the protein is one of the run's 8,000 held-out validation proteins (honest predictions inside the `train` split)
`go_{mf,bp,cc}_gogpt_ep25`, `go_{mf,bp,cc}_gogpt_ep50`	generated GO terms per aspect at that training epoch, in generation order (propagated-style sets, as trained); null where the protein has no sequence

Model: v3_run2_esm2 (8-layer / 900-d GO-GPT decoder on frozen ESM2-650M layer-27 embeddings, trained on proteins/train + proteins_extra/train, tier-1∪2 labels). Checkpoints: epoch 25 (step 61350), epoch 50 (step 122700). Decoding: greedy, temperature 0, bf16, max 200 tokens; code at gogpt commit fe60fca.

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proteins_extra_preds — GO-GPT predictions for proteins_extra

`proteins_extra_preds` — GO-GPT predictions for `proteins_extra`