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75b0e5f3-435d-425b-b82b-947c85db17a1 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is immaturity of smooth muscle cells in the neointima associated with acute coronary syndrome? | yes
Decreased positivity of h-caldesmon in neointimal smooth muscle cells is indicative of a more immature phenotype, thus may be associated with plaque vulnerability that will promote ACS. | true | en | train | medical_symptom_reasoning_medium |
304f8c12-db34-4ca9-8fab-2d0e01aeae27 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is methylation of tumor-suppressor genes in neuroblastoma : The RASSF1A gene almost always methylated in primary tumors? | yes
These results from our series indicate that hypermethylation of tumor-suppressor genes may be important in the development and evolution of NB. These epigenetic alterations could be used as a marker of the disease and genes regulating methylation should be considered as possible therapeutic targets in NB. | true | en | train | medical_disease_knowledge_medium |
c6210e48-0454-455b-aea3-a0361f8ddf7b | reasoning | medical | disease_knowledge | medium | pubmedqa | Does cerebral intravascular oxygenation correlate with mean arterial pressure in critically ill premature infants? | yes
We conclude that NIRS can be used in a noninvasive manner at the bedside to identify premature infants with impaired cerebrovascular autoregulation, that this impairment is relatively common in such infants, and that the presence of this impairment is associated with a high likelihood of occurrence of severe GMH-I... | true | en | train | medical_disease_knowledge_medium |
992c4046-5945-4b80-b432-358f436c0168 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does optimal left ventricular lead position predict reverse remodeling and survival after cardiac resynchronization therapy? | yes
Pacing at the site of latest mechanical activation, as determined by speckle tracking radial strain analysis, resulted in superior echocardiographic response after 6 months of CRT and better prognosis during long-term follow-up. | true | en | train | medical_disease_knowledge_medium |
dd1f56e5-b414-4294-b6ed-efd2974fb059 | reasoning | medical | disease_knowledge | medium | pubmedqa | Do brachytherapy Using Elastin-Like Polypeptides with ( 131 ) I Inhibit Tumor Growth in Rabbits with VX2 Liver Tumor? | yes
Elastin-like polypeptide can be an ideal carrier of (131)I and have high labeling efficiency, radiochemical purity and stability. Brachytherapy using elastin-like polypeptide with (131)I for liver tumor is a useful therapy that possesses high antitumor efficacy advantages. | true | en | train | medical_disease_knowledge_medium |
ab72c792-92a3-4a85-b07c-12eb98459848 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is serine 331 major site of phosphorylation and desensitization induced by protein kinase C in thromboxane receptor alpha? | yes
Ser-331 is the major and crucial site of receptor phosphorylation and desensitization. | true | en | train | medical_symptom_reasoning_medium |
703e0713-f8aa-406a-b7a6-ec870733c681 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Do comparison of tympanic membrane grafting medial or lateral to malleus handle? | yes
Both techniques (medial and lateral to malleus handle) of TM grafting are effective with success rates 96.42% and 92.85% respectively. | true | en | train | medical_symptom_reasoning_medium |
a3c1a870-cab3-434f-940b-6c564e5986e6 | reasoning | medical | disease_knowledge | medium | pubmedqa | Are macaca fascicularis highly susceptible to an RT-SHIV following intravaginal inoculation : a new model for microbicide evaluation? | yes
Results serve to validate the infectivity and pathogenicity of RT-SHIVtc following vaginal exposure in M. fascicularis. This RT-SHIVtc/macaque model could be suitable for the pre-clinical evaluation of non-nucleoside RT inhibitor-based anti-HIV microbicides. | true | en | train | medical_disease_knowledge_medium |
97d5f626-677b-4d30-baab-046ab5174448 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does laparoscopic live donor nephrectomy have equivalent early and late renal function outcomes compared with open donor nephrectomy? | yes
Early recovery of graft function, longer term renal function, and 3-year patient and allograft survival are similar for live donor kidneys obtained by either a laparoscopic or an open surgical technique. | true | en | train | medical_symptom_reasoning_medium |
40ab9f20-b5e5-4c89-acc3-e1329f06330c | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is chronic alcohol consumption associated with changes in the distribution , immunophenotype , and the inflammatory cytokine secretion profile of circulating dendritic cells? | yes
Chronic alcoholism in the absence of liver disease is associated with an increased secretion of inflammatory cytokines by PB DC, whereas ALCAW and ALCET patients show decreased numbers of circulating DC and reduced secretion of these cytokines, respectively. | true | en | train | medical_symptom_reasoning_medium |
e774c992-647e-4eed-bdaf-53c8a655493f | explanation | medical | symptom_reasoning | medium | bioasq | What is the role of TNF in obesity? | The role of TNF in obesity is not fully understood, but it is thought to play a major role in adipose tissue formation and fat storage. TNF-alpha is a protein that has been shown to increase fat storage in fat cells. It is also thought to have a role in insulin resistance. | true | en | train | medical_symptom_reasoning_medium |
eb143330-8176-4f44-8c67-378e05090675 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does treatment with the immunomodulator FTY720 ( fingolimod ) significantly reduce renal inflammation in murine unilateral ureteral obstruction? | yes
This study suggests that in a murine ureteral obstruction model FTY720 significantly inhibited the production of inflammatory cytokines and factors regulating interstitial fibrosis and extracellular matrix accumulation. These findings were associated with decreased evidence of renal injury on pathological examinat... | true | en | train | medical_disease_knowledge_medium |
4fec0fdc-62b2-42cd-8c33-6864cd2a6423 | reasoning | medical | symptom_reasoning | medium | bioasq | Is phosphoenolpyruvate carboxykinase 1 (PCK1) the rate-limiting enzyme in gluconeogenesis? | Yes, Pck1 is a rate-limiting gluconeogenic enzyme, where its deficiency or mutation contributes to serious clinical situations as neonatal hypoglycemia and liver failure. | true | en | train | medical_symptom_reasoning_medium |
96da4af9-d146-47ff-b4ac-5c5ed427b101 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does corticosterone selectively target endo-cortical surfaces by an osteoblast-dependent mechanism? | yes
Endocortical osteoblasts appear to be particularly sensitive to the detrimental actions of exogenous glucocorticoids. The increase in tibial pericortical cross-sectional area and the according changes in pericortical circumference suggest an anabolic bone response to GC treatment at this site. The protection of tg... | true | en | train | medical_disease_knowledge_medium |
75f61269-c06e-4179-8be6-dbd870916445 | qa | medical | symptom_reasoning | medium | bioasq | Cytochrome p450 CYP3A is induced by rifampicin and compounds used to treat what virus? | Etravirine is an effective and well-tolerated recently approved non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV type-1-infected patients with previous antiretroviral treatment experience. Etravirine is a weak inducer of cytochrome P450 (CYP)3A | true | en | train | medical_symptom_reasoning_medium |
27c20959-4e78-4616-8be5-8fe2c402348a | reasoning | medical | symptom_reasoning | medium | pubmedqa | Do circulating tumor cells count predicts survival in colorectal cancer patients? | yes
This study found that the presence of CTCs is associated with a reduced survival in colorectal cancer patients. Further studies aimed at testing such a predictive value in early stage colorectal cancer are awaited. | true | en | train | medical_symptom_reasoning_medium |
f61dc467-0632-490d-9241-00feccf9999e | reasoning | medical | disease_knowledge | medium | pubmedqa | Does universal feature in the genome-level evolution of protein domains? | yes
Both models have general quantitative agreement with data from hundreds of genomes, which indicates that the domains of a genome are built with a combination of specificity and robust self-organizing phenomena. The latter are related to the basic evolutionary 'moves' of duplication and innovation, and give rise to... | true | en | train | medical_disease_knowledge_medium |
36e6590c-7fc7-4574-bfde-c46ac3f4e9ee | reasoning | medical | disease_knowledge | medium | pubmedqa | Is gain in adiposity across 15 years associated with reduced gray matter volume in healthy women? | yes
An increase in BMI during the menopausal transition and beyond is associated with reduced GMV among otherwise healthy women. | true | en | train | medical_disease_knowledge_medium |
04f7d1d9-2434-464d-ba6b-d0330adc7b0e | qa | medical | symptom_reasoning | medium | bioasq | List the essential aminoacids. | Leucine Isoleucine Valine Tryptophan Cysteine Methionine Lysine Phenylalanine | true | en | train | medical_symptom_reasoning_medium |
60e3c69e-ee2d-48ef-a9a3-c9398d3d29c1 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is genetic ancestry associated with measures of subclinical atherosclerosis in African Americans : the Jackson Heart Study? | yes
Overall, our findings indicate that genetic ancestry was associated with subclinical atherosclerosis, suggesting unmeasured risk factors and interactions with genetic factors might contribute to the distribution of subclinical atherosclerosis among African Americans. | true | en | train | medical_disease_knowledge_medium |
cc0321cf-2654-4754-8e36-207ab1229b0f | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does a nonsense mutation ( W9X ) in CRYAA cause autosomal recessive cataract in an inbred Jewish Persian family? | yes
A nonsense mutation in the CRYAA gene causes autosomal recessive cataract in one family. This constitutes the first description of the molecular defect underlying nonsyndromic autosomal recessive congenital cataract. That there was no linkage to this locus in another family provides evidence for genetic heterogene... | true | en | train | medical_symptom_reasoning_medium |
4fa30a64-a409-4587-a426-c874340b8c90 | reasoning | medical | disease_knowledge | medium | pubmedqa | Do an update on chronic wounds and the role of biofilms? | yes
Current research is being targeted at antibiofilm strategies needed to restore an optimal wound-healing environment. A combined treatment approach involving aggressive débridement and the addition of antibiofilm agents is needed. | true | en | train | medical_disease_knowledge_medium |
9c20b6fd-5376-4893-b79e-b72cefa5a3ee | reasoning | medical | disease_knowledge | medium | pubmedqa | Does standard uptake value predict survival in non-small cell lung cancer? | yes
Local and regional maximum SUVs defined by integrated PET-CT scanning have a strong correlation with survival in patients with non-small cell lung cancer. An elevated SUV is known preoperatively and may assist clinicians in stratifying patients at increased overall risk preoperatively. | true | en | train | medical_disease_knowledge_medium |
64796f61-f814-41df-afae-4a8ee1a8c4b5 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does chronic cold exposure potentiate CRH-evoked increases in electrophysiologic activity of locus coeruleus neurons? | yes
These data, in combination with previous data, suggest that the sensitivity of LC neurons to excitatory inputs is increased following chronic cold exposure. The altered functional capacity of LC neurons in rats after continuous cold exposure may represent an experimental model to examine the role of central noradr... | true | en | train | medical_disease_knowledge_medium |
f5dfa7ca-9994-4d98-beb4-e44402268529 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does [ 3-O-β-chacotriosyl benzyl ursolate inhibit entry of H5N1 influenza virus into target cells ]? | yes
The compounds 1b, 1c and 1d showed potent inhibitory activities against the entry of A/Thailand/Kan353/2004 pseudovirus into the target cells, and among them compound 1d showed the strongest inhibitory activity with an IC50 value of 0.96 ± 0.10 µmol/L. The structure-activity relationship analysis of these compound... | true | en | train | medical_disease_knowledge_medium |
0127a133-fa39-4627-90af-e2a74e194ae1 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is invasion of the hepatic artery a crucial predictor of poor outcomes in gallbladder carcinoma? | yes
Invasion of the HA is a crucial prognostic factor in patients with gallbladder carcinoma. | true | en | train | medical_disease_knowledge_medium |
606c5d49-6300-490e-b3b0-b3053a86df24 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does radiographic response to locoregional therapy in hepatocellular carcinoma predict patient survival times? | yes
Radiographic response to LRTs predicts survival time. EASL criteria for response more consistently predicted survival times than WHO criteria. The goal of LRT should be to achieve a radiologic response, rather than to stabilize disease. | true | en | train | medical_disease_knowledge_medium |
2b805822-87ab-4e41-8003-a7af1db577ea | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does interfragmentary lag screw fixation in locking plate constructs increase stiffness in simple fracture patterns? | yes
The current biomechanical testing unveils that the insertion of a lag screw combined with a locking plate dominates over a bridging plate construct at the distal femur in terms of axial and torsional stiffness. | true | en | train | medical_symptom_reasoning_medium |
da346974-8824-4a9d-8c6a-ccab73f372e2 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is pulse wave velocity associated with metabolic syndrome components in CAPD patients? | yes
MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients. | true | en | train | medical_symptom_reasoning_medium |
c7976a98-1dd4-403b-a458-2fc5db5cfa9c | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is long-term outcome of lung transplantation predicted by the number of HLA-DR mismatches? | yes
HLA-DR mismatching appears to be a risk factor for the development of BOS and graft loss. Improved outcome after lung transplantation might be achieved with prospective matching for HLA-DR. Alternatively, the amount and type of immunosuppressive drugs may be guided by the degree of HLA-DR (mis)matching. | true | en | train | medical_symptom_reasoning_medium |
b5ac70d1-4c90-4b76-8dca-84929a62f69d | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does a novel missense mutation of CMT2P alter transcription machinery? | yes
Our findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery. Given that a similar mechanism has been reported in motor neuron degeneration of amyotrophic lateral sclerosis, abnormalities of RNA/RNA-binding protein complex may play a role in the neuronal degeneration o... | true | en | train | medical_symptom_reasoning_medium |
c925da76-4b30-44bf-b878-f85894217262 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does recombinant adenovirus-mediated vascular endothelial growth factor gene transfer attenuate hypoxia-induced apoptosis of neural stem cells in vitro? | yes
Recombinant adenovirus can efficiently mediate VEGF gene transfer into C17.2 neural stem cells, resulting in high expression of the exogenous VEGF in vitro, which effectively reduces C17.2 neural stem cell apoptosis induced by hypoxia. | true | en | train | medical_disease_knowledge_medium |
25a4a1dc-59e4-4fc9-98ad-1db846b9c858 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does serum p-cresyl sulfate predict cardiovascular disease and mortality in elderly hemodialysis patients? | yes
Our results indicate that total PCS is a valuable marker in predicting cardiovascular event and all-cause mortality in elderly HD patients. | true | en | train | medical_disease_knowledge_medium |
6d3f86e6-15e1-423f-a76e-47450d957e90 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does the ion channel ASIC1 contribute to visceral but not cutaneous mechanoreceptor function? | yes
ASIC1 influences visceral but not cutaneous mechanoreceptor function, suggesting that different mechanisms underlie mechanosensory function in gut and skin. The role of ASIC1 is highlighted by prolonging gastric emptying of a meal in ASIC1-/- animals. | true | en | train | medical_symptom_reasoning_medium |
5a7bae4a-37df-41e2-9a1a-b7a7e3653971 | reasoning | medical | disease_knowledge | medium | pubmedqa | Do fibromyalgia patients have reduced hippocampal volume compared with healthy controls? | yes
Potential mechanisms for reduced hippocampal volume in fibromyalgia include abnormal glutamate excitatory neurotransmission and glucocorticoid dysfunction; these factors can lead to neuronal atrophy, through excitotoxicity, and disrupt neurogenesis in the hippocampus. Hippocampal atrophy may play a role in memory ... | true | en | train | medical_disease_knowledge_medium |
7f73f3d1-5dcd-4ed8-8c9c-2cfe334f1985 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is cementless fixation of radial head implants affected by implant stem geometry : an in vitro study? | yes
This study shows that filling the diameter of the medullary canal is more important than filling the length of the canal. The taper did not offer any additional advantages compared to the straight stem, suggesting that reaming of bone to accept the taper did not produce enhanced initial purchase. If rigid initial ... | true | en | train | medical_disease_knowledge_medium |
e8d8ee67-fc45-4467-9bf1-e7cb06962e00 | explanation | medical | symptom_reasoning | medium | bioasq | What is ORMD-0801? | ORMD-0801 is an oral insulin capsule. Treatment with ORMD-0801 was associated with a significant 24.4% reduction in the frequencies of glucose readings >200 mg/dL (60.1 +- 7.9% pretreatment vs. 45.4 +- 4.9% during ORMD-0801 treatment; p = 0.023) and a significant mean 16.6% decrease in glucose area under the curve (AUC... | true | en | train | medical_symptom_reasoning_medium |
68a1036d-f659-4050-9b21-eeb815dc2bc8 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does impairment of anorectal function in diabetes mellitus parallel duration of disease? | yes
Patients with long-standing diabetes mellitus have increased incidence of fecal incontinence and severely impaired function of both the anal sphincters and the rectum. These findings could be attributed to the increased incidence of microangiopathy and autonomic and peripheral neuropathy observed in this subset of... | true | en | train | medical_disease_knowledge_medium |
e9e3d226-4294-49a1-8d5b-ba58337c9c24 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does state of Cerebrovascular Autoregulation correlate with Outcome in Severe Infant/Pediatric Traumatic Brain Injury? | yes
The integrity of AR seems to play the same fundamental role after TBI in the pediatric population as in adults and should be determined routinely. It carries an important prognostic value. PRx seems to be an ideal candidate parameter to guide treatment in the sense of optimizing CPP, aiming at improvement of cereb... | true | en | train | medical_symptom_reasoning_medium |
c53e8ece-01f3-4f4f-b04f-30c17eca540e | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does soluble CD163 modulate cytokine production by peripheral blood mononuclear cells stimulated by Dermatophagoides pteronyssinus allergens in vitro? | yes
In AAPs sCD163 modulates the immune response to Dp allergens potentiating anti-inflammatory, homeostatic mechanisms. | true | en | train | medical_symptom_reasoning_medium |
3e94586c-0be2-44f4-91c9-c5e4c2ed593f | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does endovenous laser ablation of great saphenous vein and perforator veins improve venous stasis ulcer healing? | yes
Ulcer healing was accomplished to a significantly greater degree using EVLA of the GSV and IPV compared to GSV ablation alone for the treatment of active VSU in patients with combined reflux. This study suggests that limbs with VSU disease should be routinely examined for both superficial axial and perforator veno... | true | en | train | medical_symptom_reasoning_medium |
1da8f61c-9635-406a-a149-0d80d6701021 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does mechanical stimulation by external application of cyclic tensile strains effectively enhance bone healing? | no
Induced cyclic tensile strains did not produce a relevant enhancement of bone healing under flexible fixation. | true | en | train | medical_symptom_reasoning_medium |
949b538e-bd39-4147-a89d-ccaff207ff1b | reasoning | medical | symptom_reasoning | medium | pubmedqa | Do neuropeptides contribute to peripheral nociceptive sensitization by regulating interleukin-1β production in keratinocytes? | yes
Collectively, these results demonstrate that neuropeptides induce nociceptive sensitization by enhancing IL-1 β production in keratinocytes. Neuropeptides rely on both caspase-1 and cathepsin B for this enhanced production. Neurocutaneous signaling involving neuropeptide activation of the innate immunity may contr... | true | en | train | medical_symptom_reasoning_medium |
b2727e1f-3000-4fbe-a00b-d285cd9cb804 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is victorian Audit of Surgical Mortality associated with improved clinical outcomes? | yes
The benefits of VASM are reflected in the association with a reduction of mortality and adverse clinical outcomes, which have clinical and financial benefits. It is a purely educational exercise and continued participation in this audit will ensure the highest standards of surgical care in Australia. This also hig... | true | en | train | medical_disease_knowledge_medium |
2a364e61-d48d-44e2-9638-065693ae8d4f | reasoning | medical | disease_knowledge | medium | pubmedqa | Is agreement between two different scoring procedures for goal attainment scaling low? | yes
The agreement between the patients' therapists scoring the goals and the independent assessor was low, signifying a large difference between the two scoring procedures. Efforts should be made to improve the reproducibility of goal attainment scaling before it is to be used as an outcome measure in blinded randomiz... | true | en | train | medical_disease_knowledge_medium |
59f1e154-cfff-4169-ba3b-3adbd33ac947 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does public access defibrillation remain out of reach for most victims of out-of-hospital sudden cardiac arrest? | yes
Despite several campaigns to raise public awareness and make PADs more available, many public areas have no recorded AED available, and in those where an AED was available it was only used in a minority of cases by members of the public before arrival of the ambulance. Overall, a PAD was only deployed successfully... | true | en | train | medical_symptom_reasoning_medium |
3b54c7d4-197d-45d8-9b1e-da90f9b47343 | qa | medical | symptom_reasoning | medium | bioasq | Which company produces Glybera? | Glybera is a product of Chiesi Pharma. | true | en | train | medical_symptom_reasoning_medium |
54c1cdd7-7c8d-4a6f-9d16-271388f4a2e1 | reasoning | medical | disease_knowledge | medium | pubmedqa | Are inflammatory biomarkers associated with total brain volume : the Framingham Heart Study? | yes
Although our observational cross-sectional data cannot establish causality, they are consistent with the hypothesis that higher inflammatory markers are associated with greater atrophy than expected for age. | true | en | train | medical_disease_knowledge_medium |
b0dbc0ad-cf20-4c73-9a59-fb024b15d826 | qa | medical | symptom_reasoning | medium | bioasq | On what chromosome is the gene for "SILVER" coat color found for the domestic cat? | Linkage mapping defined a genomic region for SILVER as a 3.3-Mb region, (95.87-99.21 Mb) on chromosome D2 in the domestic cat. | true | en | train | medical_symptom_reasoning_medium |
8239a611-9392-4235-aa3e-e9b37f5ab477 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does the prevalence and correlate of abdominal obesity in female students? | yes
The prevalence of abdominal obesity was much higher than the prevalence of general overweight and obesity. The regular recreational physical activity reduces the risk of adiposity located in the abdominal region. | true | en | train | medical_disease_knowledge_medium |
ffe13d05-4df4-445f-b24c-b456ad0d1e4f | reasoning | medical | symptom_reasoning | medium | pubmedqa | Are complex ovarian cysts in postmenopausal women associated with ovarian cancer risk factors : preliminary data from the prostate , lung , colon , and ovarian cancer screening trial? | no
Although a very small proportion of the clinically silent ovarian abnormalities found on ultrasonography are determined to be ovarian cancers, the remaining complex cysts and other clinically suspicious abnormalities do not appear to be the immediate precursors of ovarian cancer. The eventual identification of such... | true | en | train | medical_symptom_reasoning_medium |
179f8b8b-2938-481a-bc80-4dd2bba81e74 | reasoning | medical | disease_knowledge | medium | pubmedqa | Do intraoperative detection of thyroid carcinoma by fourier transform infrared spectrometry? | yes
FTIR spectroscopy technique in combination with canonical discriminant analysis method can achieve fast and accurate discrimination for malignant and benign thyroid nodules during operation. | true | en | train | medical_disease_knowledge_medium |
7ea81aff-ad80-441f-9001-4ea819db36c6 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does contralateral Oblique View be Superior to the Lateral View for Lumbar Epidural Access? | yes
This study shows that the CLO view for lumbar interlaminar epidural access offers clear advantages over the lateral view on many clinically important grounds: the needle tip visualization is better, the important radiological landmarks are better visualized, and the needle tip when placed in the epidural space pre... | true | en | train | medical_disease_knowledge_medium |
7776ec3c-3448-4b8e-8b85-23bf18580083 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does alcohol consumption increase the risk of fatal breast cancer ( United States )? | yes
This study adds to the evidence that postmenopausal women can reduce their risk of breast cancer by avoiding or minimizing their use of alcohol. | true | en | train | medical_disease_knowledge_medium |
a1d853aa-b231-49c3-a700-a2204ce127d0 | qa | medical | symptom_reasoning | medium | bioasq | In which tissues is the lincRNA Xist expressed? | Relative expression of X-linked genes was examined in liver, kidney and brain tissue by real-time PCR in adult XX(Y)* and XY* males and XX females. X-chromosome inactive specific transcript (Xist) was expressed only in female adipose tissue. X-chromosome inactive specific transcript (Xist) was expressed only in female ... | true | en | train | medical_symptom_reasoning_medium |
27eb7de1-d351-4d14-a009-b202613563d3 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does the amount of solid cerebral microemboli during carotid stenting relate to the frequency of silent ischemic lesions? | no
Solid microembolism is a common event during unprotected CAS; however, the frequency of procedure-related silent cerebral lesions appears to be independent of the number of solid cerebral microemboli during the procedure. | true | en | train | medical_symptom_reasoning_medium |
76d44723-0e40-4371-8217-e817db6a344d | reasoning | medical | symptom_reasoning | medium | pubmedqa | Do statins benefit outcomes of renal transplant recipients on a sirolimus-cyclosporine regimen? | yes
This study demonstrated compelling effects of statins against all adverse outcomes among patients treated with SRL-based, CsA-containing regimens. The profoundly dyslipidemic properties of SRL may explain these unique findings compared with previous studies on patients treated with CsA-based regimens. | true | en | train | medical_symptom_reasoning_medium |
98f88f8f-923b-4502-86ff-6413b714d4c0 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does hypoxia-ischemia brain damage disrupt brain cholesterol homeostasis in neonatal rats? | yes
The present work provides evidence that HI insult destroyed brain cholesterol homeostasis, which might be important in the molecular pathology of hypoxic-ischemic white matter injury. Proinflammatory cytokines insulting oligodendrocytes, may cause cholesterol unbalance. Furthermore, specific therapeutic interventi... | true | en | train | medical_symptom_reasoning_medium |
0c7b85e2-8f9b-47e0-b75f-2793c9b6e965 | reasoning | medical | disease_knowledge | medium | pubmedqa | Are aloin , cinnamic acid and sophorcarpidine potent inhibitors of tyrosinase? | yes
Tyrosinase activity can be greatly inhibited by cinnamic acid, aloin and sophorcarpidine, of which sophorcarpidine functions as an uncompetitive inhibitor, compared to aloin and cinnamic acid, which are mixed-type inhibitors. | true | en | train | medical_disease_knowledge_medium |
2dd20f65-f765-4411-9d9d-07d8370d1d3b | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does xenon modify mivacurium induced neuromuscular block? | no
We conclude that the neuromuscular blocking effects of mivacurium are similar when given during propofol vs xenon anesthesia. | true | en | train | medical_symptom_reasoning_medium |
46c8407f-3463-44bd-b93d-3ebb7e0722ca | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is sex ratio of babies unchanged after transfer of fast- versus slow-cleaving embryos? | yes
A greater number of boys born was not observed after transfer of faster-cleaving embryos as has been described in other animal species. The race to be male may not occur until later cleavage divisions or may not occur in the human embryo. | true | en | train | medical_symptom_reasoning_medium |
62435298-58e3-40dc-9d96-97d12af62203 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does atrial fibrillation after pulmonary lobectomy for lung cancer affect long-term survival in a prospective single-center study? | yes
AF after pulmonary lobectomy for lung cancer, in addition to causing higher hospital morbidity and mortality, predicts poorer long-term outcome in 5-year survivors. | true | en | train | medical_symptom_reasoning_medium |
8dfbbc5c-b424-426c-b04c-cb56beb35333 | explanation | medical | symptom_reasoning | medium | bioasq | What is the molecular function of psoralen photobinding on DNA? | The interaction of two water-soluble furocoumarins, 8-(omega-diethyl aminopropyloxy)psoralen hydrochloride (I) and its 5-isomer (II), with DNA has been investigated by spectroscopic, equilibrium dialysis, hydrodynamic and chiroptical techniques. Both compounds intercalate into the polynucleotide double helix. | true | en | train | medical_symptom_reasoning_medium |
f90339c1-bd1d-4fc0-b257-d0443c55e25c | reasoning | medical | disease_knowledge | medium | pubmedqa | Is daily palonosetron superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia? | yes
The daily assessments of emesis did not show significant differences between the study arms. Patients receiving palonosetron on Days 1 to 5 had significantly less severe nausea and experienced significantly less impact of CINV on daily activities on Days 6 and 7. | true | en | train | medical_disease_knowledge_medium |
ee80b84c-0118-4132-b86f-6df1f9766f46 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is cLN3P , the Batten 's disease protein , a novel palmitoyl-protein Delta-9 desaturase? | yes
We propose that palmitoyl-protein desaturation defines a new mechanism of proteolipid modification, and that deficiency of this process leads to the signs and symptoms of Batten's disease. | true | en | train | medical_disease_knowledge_medium |
58f7e3c6-f53c-4a79-a3bf-fce9dea27490 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Do physiologic and hypertonic saline solutions impair ciliary activity in vitro? | yes
LR is an isotonic solution that has no effect on CBF. Therefore it is probable that this solution is more appropriate than saline for nasal irrigation and nebulization or antral lavage. Moreover, the results of this study suggest that mucolytic effects induced by hyperosmolarity should be attained preferably with ... | true | en | train | medical_symptom_reasoning_medium |
8f98869a-c399-400f-b798-9d519b6e4786 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is the circadian rhythm of biochemical markers of bone resorption normally synchronized in breast cancer patients with bone lytic metastases independently of tumor load? | yes
This is the first study to yield information on the maintenance of the temporal program of bone turnover in bone metastatic cancer patients. Whether administration of bisphosphonates in the nighttime leads to a different outcome with respect to the current administration in the morning is a matter of future resear... | true | en | train | medical_symptom_reasoning_medium |
93125738-b40b-48f2-97ca-3043919ee6c4 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does postural steadiness during quiet stance associate with ability to recover balance in older women? | no
Our results indicate that postural steadiness during quiet stance is not predictive of ability to recover balance with the ankle strategy. Accordingly, balance assessment and fall prevention programs should individually target these two components of postural stability. | true | en | train | medical_disease_knowledge_medium |
b8d77ea1-6bbd-474a-abee-5af44b5d6502 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does use of heparin-bonded circuits in cardiopulmonary bypass improve clinical outcome? | yes
Based on several indicators, the use of heparin coating in cardiopulmonary bypass is associated with improved clinical results. | true | en | train | medical_disease_knowledge_medium |
fccfdd9e-8caa-4cd0-a700-5496a28df654 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does spring-assisted cranioplasty alter the growth vectors of adjacent cranial sutures? | yes
Application of a spring across a midline cranial suture alters the growth vector of the normal adjacent sutures. The spring greatly increases cranial width at the expense of some of the normal increase in cranial length over this period. This would be beneficial in correcting the cranial index in sagittal synostos... | true | en | train | medical_symptom_reasoning_medium |
947c5666-44de-4995-9263-f58488c40f64 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does feeding preterm infants milk with a higher dose of docosahexaenoic acid than that used in current practice influence language or behavior in early childhood : a follow-up study of a randomized controlled trial? | no
Feeding preterm infants milk containing 3 times the standard amount of DHA did not result in any clinically meaningful change to language development or behavior when assessed in early childhood. Whether longer-term effects of dietary DHA supplementation can be detected remains to be assessed. This trial was regist... | true | en | train | medical_disease_knowledge_medium |
08d10124-15c4-4a08-8f26-50fa372f4366 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is eRCC1 codon 118 polymorphism a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer? | yes
Our observations allowed us to define the first useful predictive criterion for oxaliplatin/5-FU response in patients with metastatic colorectal cancer. | true | en | train | medical_symptom_reasoning_medium |
7e72db24-237f-40f2-8112-e865770199b8 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does preoperative thrombus volume predict sac regression after endovascular aneurysm repair? | yes
Thrombus burden on preoperative CTA is a strong independent predictor of sac regression following EVAR. If validated by prospective studies, relative thrombus burden should be incorporated into postoperative surveillance algorithms to define procedural success and optimize the timing and cost-effectiveness of cros... | true | en | train | medical_disease_knowledge_medium |
054c221a-4864-4fbf-ad7f-d161b2136a7a | reasoning | medical | disease_knowledge | medium | pubmedqa | Does pretreatment with stress cortisol enhance the human systemic inflammatory response to bacterial endotoxin? | yes
In this study, transient elevation of in vivo cortisol concentrations to levels that are observed during major systemic stress enhanced a subsequent, delayed in vivo inflammatory response to endotoxin. This appeared to be a dose-dependent effect that was more prominent at intermediate concentrations of cortisol th... | true | en | train | medical_disease_knowledge_medium |
a0874296-a60d-405c-99bd-1e51387a8095 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is grade of hypospadias the only factor predicting for re-intervention after primary hypospadias repair : a multivariate analysis from a cohort of 474 patients? | yes
The grade of hypospadias remains according to our retrospective analysis the only objective independent predicting factor for re-intervention in hypospadias surgery. This finding is rather obvious for everyone operating hypospadias. Curiously midpenile hypospadias cases were doing slightly better than distal hypos... | true | en | train | medical_disease_knowledge_medium |
6e92ac0d-92bb-4a2d-b6ad-4c830058761f | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does neuronal nitric oxide synthase inhibition attenuate cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep? | yes
The present study provides evidence that neuronal NOS-derived nitric oxide plays a pivotal role in the pathogenesis of acute respiratory distress syndrome resulting from combined burn and smoke inhalation injury. | true | en | train | medical_symptom_reasoning_medium |
9a867eff-a90a-4591-ae2f-4157da2b2014 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does [ Economical impact of preterm delivery management based on fetal fibronectin result ]? | yes
By determining fFN for the diagnosis of preterm labor, we obtained savings of 4,620,000 pesos in a 6 month period avoiding unnecessary treatments and hospital stay in patients with negative fFN. Determination of fFN in cervical vaginal secretion in patients with symptoms of preterm labor showed to have high sensit... | true | en | train | medical_disease_knowledge_medium |
262a298c-dac1-49c2-b810-64ce10d0565c | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is human RECQ1 a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges? | yes
Collectively, these results provide the first evidence for a role of human RECQ1 in the response to DNA damage and chromosomal stability maintenance and point to the vital importance of RECQ1 in genome homeostasis. | true | en | train | medical_symptom_reasoning_medium |
bd806e8a-8664-481c-b34f-932c86a0e7a1 | reasoning | medical | disease_knowledge | medium | pubmedqa | Do women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes? | yes
The presence of IGT in pregnancy is predictive of poor pregnancy outcomes. | true | en | train | medical_disease_knowledge_medium |
b6ab9b55-8dc9-40e4-8418-34f4936bfa24 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does reduced diameter spheres increase the risk of chest blow-induced ventricular fibrillation ( commotio cordis )? | yes
The shape of the projectile markedly influences the risk of VF from chest wall impact. This effect is likely mediated via a greater increase in left ventricular pressure with smaller diameter objects. Spreading the impact force over a larger area may decrease the risk of sudden death and has implications for the d... | true | en | train | medical_disease_knowledge_medium |
a08822e1-5ac6-443d-bfed-02111789f415 | explanation | medical | symptom_reasoning | medium | bioasq | What is the brand name for erenumab? | Aimovig (erenumab; erenumab-aooe in the United States) is the only US Food and Drug Administration (FDA)-approved monoclonal antibody (mAb) therapy against the CGRP receptor (CGRPR) for the prevention of migraine. | true | en | train | medical_symptom_reasoning_medium |
5d14b6f4-334f-42d6-b61a-61e8c73040e9 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does nitric oxide contribute to control of effusion in experimental otitis media? | yes
The results suggest that NO is involved in regulating the permeability of the middle ear vascular, the transudation of serum into the middle ear mucosa, and/or the movement of extracellular fluid across the middle ear mucosal epithelium. | true | en | train | medical_disease_knowledge_medium |
b4acbd8b-2319-4d39-96af-9c9d1b0f257c | reasoning | medical | disease_knowledge | medium | pubmedqa | Does hydrogen peroxide affect specific epithelial subpopulations in cultured rabbit lenses? | yes
Cells in the peripheral region of cultured lenses were more resistant to H2O2 cytotoxicity than cells in the central and pre-equatorial regions. The antioxidant defense or repair systems for H2O2-induced damage do not appear to be uniformly distributed in subpopulations of the lens epithelium. | true | en | train | medical_disease_knowledge_medium |
1d824527-35ae-4b6b-815e-5ec421123399 | reasoning | medical | disease_knowledge | medium | pubmedqa | Do hepatocytes internalize trophic receptors at large endocytic `` Hot Spots ''? | yes
These findings suggest that hepatocytes sequester or prerecruit both structural and enzymatic components of the clathrin-based endocytic machinery to functional hot spots, from which large numbers of coated pits form and vesicles are generated. This process may mimic the endocytic organization found at the synapse... | true | en | train | medical_disease_knowledge_medium |
246d528e-dbd8-453c-9427-798d57c7bd8f | reasoning | medical | disease_knowledge | medium | pubmedqa | Does adjustment of the ratio between collagenase class II and I improve islet isolation outcome? | yes
The present study indicates that the ratio between ccII and ccI is of significant relevance for optimizing islet yield and viability. | true | en | train | medical_disease_knowledge_medium |
ea86fb3f-988c-40fb-9686-193f40fe6f9b | reasoning | medical | disease_knowledge | medium | pubmedqa | Is increased preoperative levels of plasma fibrinogen and D dimer in patients with renal cell carcinoma associated with poor survival and adverse tumor characteristics? | yes
Increased plasma fibrinogen levels accurately predict poor histopathologic and survival outcomes and may be an effective independent prognostic factor in patients with RCC. Moreover, d dimer may serve as a copredictive factor in conjunction with fibrinogen. | true | en | train | medical_disease_knowledge_medium |
6ee4903e-ff00-4f4c-87eb-e1af64085f75 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does pathological Internet Use be on the Rise Among European Adolescents? | yes
Our findings are the first data to confirm the rise of PIU among European adolescents. They definitively warrant further efforts in the implementation and evaluation of preventive interventions. | true | en | train | medical_disease_knowledge_medium |
1b152ccd-abe0-4ced-afb4-b7fb74b2b83e | reasoning | medical | disease_knowledge | medium | pubmedqa | Does attending Handoff be Correlated with the Decision to Delay Extubation After Surgery? | yes
Attending handoff was an independent significant factor that increased the risk for the delay of extubation at the end of a surgical case. | true | en | train | medical_disease_knowledge_medium |
80d0eeac-04f7-44d7-af33-69aae58740a8 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does preservation of basal AcSDKP attenuate carbon tetrachloride-induced fibrosis in the rat liver? | yes
Maintaining physiological levels of AcSDKP is critical in negatively regulating the development of fibrosis in chronic liver injury. Preservation of AcSDKP may be a useful therapeutic approach in the management of liver fibrosis. | true | en | train | medical_symptom_reasoning_medium |
cd58f9f8-ae86-4e84-9521-7c3a8724abba | reasoning | medical | disease_knowledge | medium | pubmedqa | Is blunt cerebrovascular injury poorly predicted by modeling with other injuries : analysis of NTDB data? | yes
A model based on a pattern of other injuries cannot be used as a stand-alone instrument to determine screening for BCVI. "Optimal" model cut-points are not ideal for all injuries. Clinical suspicion that integrates energy of mechanism and associated injuries remains essential to effectively screen for BCVI and min... | true | en | train | medical_disease_knowledge_medium |
f287cb67-2aa4-4d24-97d8-dd86d641aa96 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is human angiopoietin gene expression a marker for severity of pulmonary hypertension in patients undergoing pulmonary thromboendarterectomy? | yes
Angiopoietin-1, a gene responsible for vessel development in the embryonic lung, is up-regulated in the lung parenchyma of patients with pulmonary hypertension. The level of expression of angiopoietin-1 at messenger RNA and protein levels correlates to the severity of pulmonary hypertension in patients with thromb... | true | en | train | medical_symptom_reasoning_medium |
7afa9d63-d61b-45e2-9a4c-56347fc38291 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does monitoring orbicularis oculi predict good intubating conditions after vecuronium in children? | yes
Following administration of 0.15 mg.kg-1 vecuronium in children, monitoring of the OO can detect good intubating conditions 0.7 min earlier than with monitoring of the AP. | true | en | train | medical_disease_knowledge_medium |
d549863e-7ec4-4f15-9daa-7c72315f55f8 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Is decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy ( infliximab ) in rheumatoid arthritis associated with clinical improvement? | yes
Anti-TNFalpha treatment in rheumatoid arthritis results in a decrease in the serum titres of RF and anti-CCP antibodies in patients showing clinical improvement, suggesting that these measurements may be a useful adjunct in assessing treatment efficacy. | true | en | train | medical_symptom_reasoning_medium |
ab1469c8-4912-49cb-ad8f-6092366b59b5 | reasoning | medical | symptom_reasoning | medium | pubmedqa | Does leukoaraiosis predict the need for intraoperative shunt placement during carotid endarterectomy? | yes
Ipsilateral WMHL volume is a significant predictive factor for shunt requirement during carotid endarterectomy. This may reflect cerebral hemodynamic compromise. | true | en | train | medical_symptom_reasoning_medium |
c8a22b90-0419-4e7a-b356-a13becc0eeae | reasoning | medical | symptom_reasoning | medium | pubmedqa | Do mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters? | yes
The amino acid transporters located at the apical side of the syncytiotrophoblast (STB) manage uptake of MeHg. Mercury conjugated to glutathione (GSH) is effluxed via MRP1 localized to the basal side of the STB. The findings can well explain why mercury is transported primarily towards the fetal side. | true | en | train | medical_symptom_reasoning_medium |
e72b3eb8-7791-4aa5-9989-bdef0ed2e4d7 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does tai chi diminish oxidative stress in Mexican older adults? | yes
Our findings suggest that the daily practice of Tai Chi is useful for reducing OxS in healthy older adults. | true | en | train | medical_disease_knowledge_medium |
61e5bc98-e454-4ec4-aa54-45bd9e51835e | reasoning | medical | disease_knowledge | medium | pubmedqa | Does clustering of chronic rhinosinusitis symptomatology reveal novel associations with objective clinical and demographic characteristics? | yes
Variability in SNOT-22 scores from CRS patients may be explained by the independent presence of sleep, nasal, otologic, and emotional function symptoms, with which we find novel clinical and demographic associations. These findings may represent clinical evidence for distinct pathophysiologic processes that differ... | true | en | train | medical_disease_knowledge_medium |
564764e0-74a0-4396-9809-4460acccd930 | reasoning | medical | disease_knowledge | medium | pubmedqa | Is elevated cord serum manganese level associated with a neonatal high ponderal index? | yes
Higher prenatal Mn exposure, even at a low level, is associated with a higher prevalence of HPI in a nonlinear pattern. Cord serum Mn levels less than 5.0μg/L may be considered safe with respect to neonatal ponderal index assessment. | true | en | train | medical_disease_knowledge_medium |
716af7eb-ead3-451d-b97b-43ed47357e50 | qa | medical | symptom_reasoning | medium | bioasq | Which was the first adeno-associated virus vector gene therapy product approved in the United States? | The first adeno-associated virus vector gene therapy product in the United States was Luxturna. | true | en | train | medical_symptom_reasoning_medium |
3d56a9ae-844e-45b7-a579-fbe0c0f61788 | reasoning | medical | disease_knowledge | medium | pubmedqa | Does strength of antimicrobial bone cement decrease with increased poragen fraction? | yes
The use of poragens can increase elution of antimicrobials from antimicrobial-loaded bone cement. However, for implant fixation, to avoid deleterious reduction of compressive strength, the amount of poragen that can be added in addition to 1 g of antimicrobial powder may be limited to 2 g per batch. | true | en | train | medical_disease_knowledge_medium |
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