biodatlab/ec-raft
Text Generation • Updated • 19
data stringlengths 62 36k | criteria stringlengths 174 19.2k | NCT_ID stringlengths 11 11 | metadata dict |
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#Study Description
Brief Summary
The overall goal of this research is to develop a platform that can increase patient access to expert skin cancer diagnostic services via telemedicine. This is especially important for medically underserved areas where melanoma outcomes are worse than in areas with greater access to i... | #Eligibility Criteria:
Inclusion Criteria:
* Be 18 years or older
* Have 1 <= age <= 3 lesions for evaluation
Exclusion Criteria:
* Lesions of the hair-bearing scalp, in the mouth, on the lips, genitalia, nails, on/around the eyes, inside the ear
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Maximum Age : 90 Years
... | NCT04411810 | {
"brief_title": "SpotCheck: Comparison of Enhanced Telemedicine Versus In-person Evaluation for the Diagnosis of Skin Cancer",
"conditions": [
"Skin Cancer"
],
"interventions": [
"Device: Nevisense 3.0",
"Procedure: Skin biopsy",
"Device: Dermlite Cam",
"Device: Barco Demetra"
],
"locat... |
#Study Description
Brief Summary
The purpose of this study is to test SU011248 (sunitinib) in combination with paclitaxel/carboplatin. This combination regimen will be tested for safety and antitumor activity.
#Intervention
- DRUG : carboplatin + SU011248 (sunitinib) + paclitaxel
- AUC of 6 mg\*min/mL administere... | #Eligibility Criteria:
Inclusion Criteria:
* Histologically or cytologically proven diagnosis of any advanced solid malignancy that is not amenable to treatment with curative intent
* Candidates for treatment with carboplatin and paclitaxel with maximum of 2 prior chemotherapy regimens
* ECOG performance status 0 or 1... | NCT00511849 | {
"brief_title": "Study Of SU011248 In Combination With Paclitaxel/Carboplatin In Patients With Advanced Solid Tumors",
"conditions": [
"Neoplasms"
],
"interventions": [
"Drug: carboplatin + SU011248 (sunitinib) + paclitaxel"
],
"location_countries": [
"United States"
],
"nct_id": "NCT005118... |
#Study Description
Brief Summary
The primary objective of this study is to substantiate prediction accuracy(with a tighter 95% confidence interval compared to current diagnostic modalities), of a lung cancer biomarker for risk stratification of patients into high and low risk categories to aid in clinical evaluation ... | #Eligibility Criteria:
Inclusion Criteria:
* The patient is being evaluated for the diagnosis of possible lung cancer or 'rule out lung cancer' and is indicated for bronchoscopy.
* The patient is undergoing bronchoscopy
* >= 21 years
* Patient meets local site's standard of care (SOC) for performing diagnostic broncho... | NCT01309087 | {
"brief_title": "Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS CLIA",
"conditions": [
"Lung Cancer"
],
"interventions": null,
"location_countries": [
"Canada",
"Ireland",
"United States"
],
"nct_id": "NCT01309087",
"official_title": "Airway Epithelium Gene Exp... |
#Study Description
Brief Summary
The aim of the present study is to evaluate an innovative virtual reality-based balance training intervention for improving clinically relevant motor performances (balance and gait) in people with mild cognitive impairment.
The investigators hypothesize that the virtual reality-based... | #Eligibility Criteria:
Inclusion Criteria:
* diagnosis of Mild Cognitive Impairment
* willingness to provide informed consent
Exclusion Criteria:
* severe neurologic, cardiovascular, metabolic, or psychiatric disorders
* severe visual impairment
* severe cognitive impairment
* dementia
Sex :
ALL
Ages :
- Age Grou... | NCT02214342 | {
"brief_title": "Virtual Reality Based Balance Training in People With Mild Cognitive Impairment",
"conditions": [
"Distorted; Balance",
"Motor Deficit",
"Cognitive Deficit"
],
"interventions": [
"Other: Balance Training"
],
"location_countries": [
"United States"
],
"nct_id": "NCT0... |
#Study Description
Brief Summary
The purpose of this study is to demonstrate safety and efficacy of SH T00660AA compared to placebo in the treatment of endometriosis
Detailed Description
The study has previously been posted by Schering AG, Germany. Schering AG, Germany has been renamed to Bayer Schering Pharma AG, ... | #Eligibility Criteria:
Inclusion Criteria:
* Female patients with endometriosis-associated pelvic pain
Exclusion Criteria:
* Pregnant or lactating women
* history or suspicion of hormone dependent tumor
* therapy resistant endometriosis
* need for primary surgical treatment
* any other conditions which forbid the pa... | NCT00225199 | {
"brief_title": "Efficacy and Safety of SH T00660AA in Treatment of Endometriosis",
"conditions": [
"Endometriosis"
],
"interventions": [
"Drug: Placebo",
"Drug: Visanne (BAY86-5258, SH T00660AA)"
],
"location_countries": null,
"nct_id": "NCT00225199",
"official_title": "A Multicenter, Doub... |
#Study Description
Brief Summary
The purpose of this study is to determine the effect of a pre-discharge written personal endorsement to the patient by the patient's attending cardiologist or cardiac surgeon (MD endorsement) to take part in the Cardiac Rehabilitation and Secondary Prevention (CR) program, in addition... | #Eligibility Criteria:
Inclusion Criteria:
* Patient is admitted to hospital for myocardial infarction (MI), unstable angina (UA), percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass surgery (CABS)
* Patient resides within 1 hour driving time from London
Exclusion Criteria:
* Inability t... | NCT00336830 | {
"brief_title": "Improving Cardiac Rehabilitation Participation in Women and Men",
"conditions": [
"Myocardial Infarction",
"Unstable Angina",
"Coronary Disease"
],
"interventions": [
"Behavioral: Standard Cardiac Rehabilitation referral",
"Behavioral: MD-endorsed Cardiac Rehabilitation ref... |
#Study Description
Brief Summary
This is a prospective, observational study, aimed to establish the relationship between an inefficient endogenous pain modulation before surgery (total knee arthroplasty; TKA) and the probability to develop chronic pain after surgery (persistent post surgical pain). Endogenous analges... | #Eligibility Criteria:
Inclusion Criteria:
* >= 18 years patients
* Scheduled for primary total knee arthroplasty
* Disposition to visits and scheduled tests
Exclusion Criteria:
* Previous surgery on knee to be operated
* Documented peripheral neuropathy
* Severe disease or condition that could potentially interfere... | NCT01811888 | {
"brief_title": "Painful Knee Prosthesis. Relationship Between Endogenous Analgesia and Persistent Post Surgical Pain.",
"conditions": [
"Knee Osteoarthritis"
],
"interventions": [
"Behavioral: Quantitative sensory testing (QST)"
],
"location_countries": [
"Spain"
],
"nct_id": "NCT01811888"... |
#Study Description
Brief Summary
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation D... | #Eligibility Criteria:
Inclusion Criteria for patients with disc herniation:
* Diagnosis of disc herniation (protrusion, extrusion, sequestered disc)
* not an indication for lumbar disc herniation surgery
* for patients with neurological deficits, loss of strength, decrease in DTRs, loss of sensation and at least one ... | NCT04912388 | {
"brief_title": "Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise",
"conditions": [
"Low Back Pain"
],
"interventions": [
"Other: Lumbal stabilization excercises",
"Other: Conventional exercises"
],
"location_countries": [
"Turkey"
],
"nct_id":... |
#Study Description
Brief Summary
This is an open-label, non-randomized, phase II, single arm, multi-center controlled clinical trial.
47 patients will be enrolled in this trial to determine the efficacy and safety of Bintrafusp alfa (M7824) in advanced malignant pleural mesothelioma patients previously treated with ... | #Eligibility Criteria:
Inclusion Criteria:
* Male or female subjects aged >= 18 years and capable of giving signed informed consent or requirement per local legislation.
* ECOG performance status of 0 <= age <= 2.
* Histologically confirmed malignant pleural mesothelioma (all histological subtypes are eligible), unres... | NCT05005429 | {
"brief_title": "Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural Mesothelioma",
"conditions": [
"Mesothelioma; Lung"
],
"interventions": [
"Drug: Bintrafusp alfa"
],
"location_countries": [
"Spain"
],
"nct_id": "NCT05005429",
"offic... |
#Study Description
Brief Summary
In this trial the investigators will evaluate the outcomes of 4 pre-defined groups of individuals according to the therapeutic intervention. The investigators will determine the outcome of each group by monitoring the survival and the response rates of patients with FLT3-ITD AML relap... | #Eligibility Criteria:
Inclusion Criteria:
* Histology/PCR proven relapse of FLT3-ITD+ AML after allo-HSCT
* Age >=18 years
* Treatment with either chemotherapy-alone, chemotherapy/DLI, sorafenib alone or sorafenib/DLI
* Written informed consent
* Ability to understand the nature of the study and the study related pro... | NCT02867891 | {
"brief_title": "Sorafenib In Relapse of FMS-like Tyrosine Kinase 3 (FLT3)-Internal Tandem Duplication (ITD) AML Trial",
"conditions": [
"Acute Myeloid Leukemia"
],
"interventions": null,
"location_countries": null,
"nct_id": "NCT02867891",
"official_title": "Multicenter, Observational Trial to Deter... |
#Study Description
Brief Summary
The purpose of the study is to determine if an oral ketone beverage is safe and well-tolerated during moderate intensity exercise in participants with long-chain fatty acid oxidation disorders and if it will raise blood ketones to levels similar to that reported among normal healthy s... | #Eligibility Criteria:
Inclusion Criteria:
* confirmed diagnosis of VLCAD, LCHAD/TFP or CPT2 deficiency
* speak English
* willing to complete 2 moderate intensity exercise treadmills
Exclusion Criteria:
* subjects actively participating in another research study that prohibits their participation
* pregnant females
... | NCT05411835 | {
"brief_title": "Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders",
"conditions": [
"Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency",
"Carnitine Palmitoyltransferase Deficiency 2",
"Very Long Chain Acyl Coa Dehydrogenase Deficiency",
"Trifunctional Prot... |
#Study Description
Brief Summary
This is designated to validate patient-reported outcomes (PRO) measures in itch-specific pediatric skin conditions, such as atopic dermatitis, and examine the ability of a modified stigma instrument to assess the severity and type of stigma experienced in atopic dermatitis and other p... | #Eligibility Criteria:
Inclusion Criteria:
* Affected children must have moderate to severe AD or another skin condition that causes itch, experience itch, understand English, and be able to complete an English-based survey
* Any child with a potentially disfiguring skin condition or change in appearance related to di... | NCT03051347 | {
"brief_title": "Asthma and Atopic Dermatitis Validation of PROMIS Pediatric Instruments",
"conditions": [
"Atopic Dermatitis",
"Ichthyosis",
"Psoriasis"
],
"interventions": [
"Other: Itch Questionnaire and Interview",
"Other: Cognitive Interview and PROMIS Itch Questionnaire",
"Other: ... |
#Study Description
Brief Summary
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of product use.
#Intervention
- DRUG : Test
- test toothpa... | #Eligibility Criteria:
Inclusion Criteria:
* Potential subjects must meet all of the following criteria
* Subjects, ages 18 <= age <= 70, inclusive
* Availability for the six-month duration of the clinical research study
* Good general health
* Initial gingivitis index of at least 1.0 as determined by the use of the L... | NCT06300866 | {
"brief_title": "Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste",
"conditions": [
"Gingivitis",
"Plaque, Dental"
],
"interventions": [
"Drug: Test",
"Drug: Control"
],
"location_countries": [
"United States"
],
"nct_id": "NCT06300866",
"official_title": "The ... |
#Study Description
Brief Summary
Type 2 Diabetes (TD2) is the leading cause of new cases of preventable blindness in these countries (and the gold-standard treatment, laser photocoagulation has proven to be effective in preventing vision loss at the end stage of eye disease due to proliferative diabetic retinopathy (... | #Eligibility Criteria:
Inclusion Criteria:
* type 2 diabetic patients
* patient with proliferative diabetic retinopathy (for arm 1)
* patient with non proliferative diabetic retinopathy (for arm 2)
* patient older than 18 years
* patient consenting to participate to the study
* patient enrolled in the national healthc... | NCT02879422 | {
"brief_title": "Genetic Markers and Proliferative Diabetic Retinopathy",
"conditions": [
"Proliferative Diabetic Retinopathy"
],
"interventions": [
"Genetic: genetic analysis"
],
"location_countries": [
"France"
],
"nct_id": "NCT02879422",
"official_title": "Study of the Association Betw... |
#Study Description
Brief Summary
Omega-3 fatty acids are provided through dietary intake of fish and seafood. Several dietary supplements containing omega-3 fatty acids are also commercially available. Some studies have described beneficial effects from omega-3 fatty acids, among them are anti-inflammatory, anti-thro... | #Eligibility Criteria:
Inclusion Criteria:
* Patients over the age of 18 who have received a kidney transplant. Patients with a functioning kidney transplant, defined as eGFR>30 ml/min. Signed informed consent.
Exclusion Criteria:
* Patients participating in clinical trials with other investigational drugs. Patients... | NCT01744067 | {
"brief_title": "The Effects of Omega-3 Fatty Acids in Renal Transplantation",
"conditions": [
"Disorder Related to Renal Transplantation"
],
"interventions": [
"Drug: Placebo",
"Drug: Omega-3 fatty acids"
],
"location_countries": [
"Norway"
],
"nct_id": "NCT01744067",
"official_title... |
#Study Description
Brief Summary
This study aims to analyze the factors influencing the abortion interval of second-trimester termination of pregnancy using misoprostol.
Detailed Description
Misoprostol is the primary drug of choice for medical termination. It is not only cheap, but also stable at room temperature ... | #Eligibility Criteria:
Inclusion Criteria:
*All female patients who were admitted for medical termination of second-trimester pregnancy
Exclusion Criteria:
* Patients who are allergy to Cytotec.
Sex :
FEMALE
Ages :
- Minimum Age : 13 Years
- Maximum Age : 50 Years
- Age Group (Child: birth-17, Adult: 18-64, Older... | NCT01927822 | {
"brief_title": "Factors Influencing the Abortion Interval of Second-trimester Termination of Pregnancy Using Misoprostol",
"conditions": [
"Labor Induction"
],
"interventions": null,
"location_countries": [
"Taiwan"
],
"nct_id": "NCT01927822",
"official_title": null,
"recruitment_information... |
#Study Description
Brief Summary
The study is to measure how dense or solid the infant's bones are using a new ultrasound machine and how that density changes over time.
Detailed Description
premature infants weighing less than 1500 gms and less than 33 weeks gestation are eligible for the study
#Intervention
- D... | #Eligibility Criteria:
Inclusion Criteria:
* premature infants born less than 33 weeks, weighing less than 1500 gms
Exclusion Criteria:
* congenital anomalies weight greater than 1500 gms
Sex :
ALL
Ages :
- Minimum Age : 24 Weeks
- Maximum Age : 33 Weeks
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65... | NCT00631397 | {
"brief_title": "A Preliminary Study of Bone Density in Neonates",
"conditions": [
"Osteopenia Of Prematurity"
],
"interventions": [
"Device: Ultrasound machine"
],
"location_countries": [
"United States"
],
"nct_id": "NCT00631397",
"official_title": "A Preliminary Study of Bone Density M... |
#Study Description
Brief Summary
The purpose of this study is to evaluate the effect of immediate versus deferred indinavir (IDV) in addition to background therapy on disease progression or death in patients with CD4+ cell counts between 200 and 500 cells/mm3 and plasma HIV RNA levels \>= 10,000 copies/ml.
This stud... | #Eligibility Criteria:
Inclusion Criteria
Concurrent Medication:
Allowed:
* Topical and/or antifungal agents, except ketoconazole.
* Treatment, maintenance, or chemoprophylaxis with approved agents for OIs will be given as clinically indicated.
* Clinically indicated antibiotics, unless excluded.
* Systemic corticos... | NCT00000861 | {
"brief_title": "The Addition of Indinavir to Anti-HIV Treatment in HIV-Infected Patients",
"conditions": [
"HIV Infections"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT00000861",
"official_title": "A Randomized Trial of Immediate Versus Deferred Indinavir... |
#Study Description
Brief Summary
This is retrospective research mainly aims to determine the patterns of symptoms, clinical and radiological findings and outcomes in patients with trigeminal neuropathy following trauma or iatrogenic damage and how this translates into costs for the patient and society, work disabilit... | #Eligibility Criteria:
Inclusion Criteria:
* Presentation with post traumatic, iatrogenic, injury of the trigeminal nerve or its branches (eg. inferior alveolar nerve, lingual nerve)
* Iatrogenic nerve injury caused by M3 removal, implant placement, orthognathic surgery, endodontic therapy, non-M3 removal, local anest... | NCT04612855 | {
"brief_title": "Post-traumatic Neuropathy of the Trigeminal Nerve",
"conditions": [
"Nerve Injury",
"Orofacial Pain",
"Trigeminal Nerve Injuries",
"Trigeminal Neuropathy"
],
"interventions": [
"Other: Groupwise comparison of primary and secondary outcomes"
],
"location_countries": [
... |
#Study Description
Brief Summary
This study adopted a practical approach in intermittent cooling on forehead and neck during an intra-squad baseball game. Exit velocity of batted balls was used as an indicator for hitting performance and a baseball-specific reactive agility test to evaluate the cognitive performance ... | #Eligibility Criteria:
Inclusion Criteria:
* baseball players from National Taiwan University of Sport, Taiwan
* at least 6 years of experience in baseball training
* have competed nationally.
Exclusion Criteria:
* having cardiovascular or other known chronic diseases
* taking any medication in the preceding 2 month... | NCT05068804 | {
"brief_title": "Intermittent Cooling During Baseball Games on Hitting and Defense Performance",
"conditions": [
"Decline, Cognitive"
],
"interventions": [
"Other: control",
"Procedure: Cooling"
],
"location_countries": [
"Taiwan"
],
"nct_id": "NCT05068804",
"official_title": "Intermi... |
#Study Description
Brief Summary
The purpose of this study is to see if Arimidex, an aromatase inhibitor, can delay epiphyseal fusion and increase predicted adult height in boys who are growth hormone deficient, in puberty, and who are taking growth hormone. This is a double blind, placebo controlled 3 year trial.
#... | #Eligibility Criteria:
Inclusion Criteria:
* Growth hormone deficient by formal testing with two provocative agents.
* Treated with growth hormone for a minimum of 6 months prior to study entry.
* Growth hormone doses must be maintained at 0.2 <= age <= 0.4mg/kg/wk while in protocol.
* Stable organic pathology
* Prese... | NCT00133354 | {
"brief_title": "Arimidex Multicenter Trial in Growth Hormone (GH) Deficient Boys",
"conditions": [
"Hypopituitarism"
],
"interventions": [
"Drug: Arimidex (Anastrozole)",
"Drug: Placebo",
"Drug: Growth Hormone"
],
"location_countries": [
"United States"
],
"nct_id": "NCT00133354",
... |
#Study Description
Brief Summary
This is an observational study, hence there is no study hypothesis
#Intervention
- OTHER : Patients using Wilate as standard of care
- Patients with von Willebrand Disease using Wilate for a period of 2 years. | #Eligibility Criteria:
Inclusion Criteria:
* Patients with a diagnosis of von Willebrand Disease who have been prescribed Wilate
Sex :
ALL
Ages :
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT, CHILD
Accepts Healthy Volunteers:
No
| NCT01602419 | {
"brief_title": "Surveillance of Safety and Efficacy of Wilate in Patients With Von Willebrand Disease",
"conditions": [
"Von Willebrand Disease"
],
"interventions": [
"Other: Patients using Wilate as standard of care"
],
"location_countries": [
"Sweden",
"United States",
"Portugal",
... |
#Study Description
Brief Summary
This study is being conducted to evaluate the hypothesis that use of pharmacological and non-pharmacological interventions may allow subjects at high risk for chronic migraine to avoid or reverse the transformation of episodic migraine to chronic migraine.
Detailed Description
Two i... | #Eligibility Criteria:
Inclusion Criteria:
Subject
* Is male or female, in otherwise good health, 18 <= age <= 65 of age.
* Has history of frequent episodic migraine (6 <= age <= 14 migraine days per month) (with or without aura) according to the 2nd Edition of The International Headache Classification (ICHD-2) for a... | NCT01300546 | {
"brief_title": "Treximet Trademark (TM) in the Prevention and Modification of Disease Progression in Migraine",
"conditions": [
"Migraine"
],
"interventions": [
"Drug: Naproxen Sodium",
"Drug: Sumatriptan/Naproxen Sodium"
],
"location_countries": [
"United States"
],
"nct_id": "NCT0130... |
#Study Description
Brief Summary
Inaccuracy of laboratory medicine diagnostic tests may be associated with ingestion of over-the-counter biotin supplements.
Detailed Description
Study group 1) Due to a lack of systematic studies, little is known about how performance of specific biotinylated immunoassays is associa... | #Eligibility Criteria:
Inclusion Criteria:
* Age above 18 years
* Apparently healthy
Exclusion Criteria:
* Pre-existing condition other than hypothyroidism
* Intake of dietary supplements containing biotin
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OL... | NCT03995277 | {
"brief_title": "Effect of Biotin on Routine Laboratory Values",
"conditions": [
"Biotin Ingestion",
"Interference With Routine Analyical Tests"
],
"interventions": [
"Dietary Supplement: Biotin"
],
"location_countries": [
"Germany"
],
"nct_id": "NCT03995277",
"official_title": "Inves... |
#Study Description
Brief Summary
The main objective of this project is to evaluate the effects sought and the effects felt by children when EMONO is used in pediatric dental care. The Investigators will try to characterize the children who have submitted a request to extend contact with EMONO. The maintenance of a fr... | #Eligibility Criteria:
Inclusion Criteria:
* Children aged 3 to 15, requiring care under MEOPA
Exclusion Criteria:
* Do not fit into the inclusion criteria
Sex :
ALL
Ages :
- Minimum Age : 3 Years
- Maximum Age : 15 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : CHILD
Accepts Healthy Volun... | NCT03453411 | {
"brief_title": "Effects of EMONO in Children During Dental Care",
"conditions": [
"Dental Care"
],
"interventions": [
"Other: Non interventional study"
],
"location_countries": [
"France"
],
"nct_id": "NCT03453411",
"official_title": "Multicentre, Prospective, Uncontrolled Study to Descr... |
#Study Description
Brief Summary
A cross-sectional analysis of prevalence data from a stratified sample of 23 countries used to estimate the global need for palliative care for children aged 0-19 years. Prevalence data, from the Institute for Health Metrics and Evaluation, was for 12 major diagnostic groups needing c... | #Eligibility Criteria:
Inclusion Criteria:
* have one of the conditions above
Exclusion Criteria:
* greater than 19 years
Sex :
ALL
Ages :
- Maximum Age : 19 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : ADULT, CHILD
Accepts Healthy Volunteers:
Yes
| NCT02553148 | {
"brief_title": "Estimating the Global Need for Palliative Care for Children",
"conditions": [
"Cancer",
"Congenital Anomalies",
"Cardiovascular Disease",
"HIV"
],
"interventions": [
"Other: Need for children's palliative care"
],
"location_countries": [
"United States"
],
"nct_... |
#Study Description
Brief Summary
This randomized clinical trial studies ABH (lorazepam, diphenhydramine hydrochloride, and haloperidol) gel in patients with nausea. ABH gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting. The general purpose of this research study is to improve the... | #Eligibility Criteria:
Inclusion Criteria:
* English speaking
* No allergies to the drugs
* Able to complete the forms
* If a woman of childbearing age, agree to use contraception; women will be offered a pregnancy test before doing the trial if they request one, as stated in the Informed Consent Form
* Patients must ... | NCT01556932 | {
"brief_title": "Randomized Trial of the Effectiveness of Topical 'ABH Gel' vs. Placebo in Cancer Patients With Nausea",
"conditions": [
"Nausea",
"Vomiting"
],
"interventions": [
"Drug: ABH gel",
"Other: placebo"
],
"location_countries": [
"United States"
],
"nct_id": "NCT01556932"... |
#Study Description
Brief Summary
The investigators are looking to see if a certain dose of stereotactic body radiation therapy (SBRT) may be a viable treatment option for recurrent or residual pancreatic or periampullary adenocarcinoma.
Detailed Description
No standard treatment option has yet been established for ... | #Eligibility Criteria:
Inclusion Criteria:
* 18 years or older
* Karnofsky Performance Status greater than or equal to 70%
* confirmed pancreatic or periampullary adenocarcinoma
* pancreatic or periampullary tumor less than 8.0 cm in greatest axial dimension
* Either:
* standard of care treatment for pancreatic can... | NCT01781728 | {
"brief_title": "Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma",
"conditions": [
"Pancreatic Cancer",
"Periampullary Adenocarcinoma"
],
"interventions": [
"Radiation: Stereotactic Body Radiation Therapy (SBRT)"
],
"location_countries": [
"United States"
... |
#Study Description
Brief Summary
The purpose of this study is to compare bedside rounding with hallway and conference room rounding on the neurology inpatient ward service at an academic hospital and identify best practices associated with educational and patient care outcomes. Specifically, this study will determine... | #Eligibility Criteria:
Inclusion Criteria:
* new admission to neurology team
Exclusion Criteria:
* comfort measures as sole treatment goal
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Maximum Age : 100 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT
Accepts Healthy Volunte... | NCT04754828 | {
"brief_title": "A Study of Bedside Versus Hallway Rounding",
"conditions": [
"Education, Medical"
],
"interventions": [
"Other: Assigned to a rounding style"
],
"location_countries": [
"United States"
],
"nct_id": "NCT04754828",
"official_title": "A Study of Bedside Versus Hallway Roundi... |
#Study Description
Brief Summary
This study aimed to research the effect of different general anesthesia administration on postoperative smell functions and memory.
#Intervention
- DIAGNOSTIC_TEST : butanol threshold test and smell identification tests
- no additional intervention | #Eligibility Criteria:
Inclusion Criteria:
* American Society of Anesthesiologists (ASA) I-II risk groups
* operated under elective conditions with general anesthesia requiring intubation
* operation durations of 40 <= age <= 180 minutes.
Exclusion Criteria:
* intracranial,
* endocrine or nasal surgery,
* pregnant c... | NCT05499845 | {
"brief_title": "Effects of Different Anesthesia on Odor Memory",
"conditions": [
"Smell Functions",
"Odor Memory"
],
"interventions": [
"Diagnostic Test: butanol threshold test and smell identification tests"
],
"location_countries": [
"Turkey"
],
"nct_id": "NCT05499845",
"official_t... |
#Study Description
Brief Summary
A retrospective analysis of historical data looking at hematological remission and survival in adult relapsed / refractory B-precursor acute lymphoblastic leukemia patients.
Detailed Description
A retrospective observational study reviewing historical survival data (hematological re... | #Eligibility Criteria:
Inclusion Criteria:
* adult patients with relapsed / refractory B-precursor acute lymphoblastic leukemia
* age >= 15 years at time of de novo (initial) diagnosis of acute lymphoblastic leukemia
* initial diagnosis of acute lymphoblastic leukemia in the year 1990 or later
* No CNS involvement at ... | NCT02003612 | {
"brief_title": "Historical Data Analysis of Hematological Remission and Survival in Adults With R/R Acute Lymphoblastic Leukemia",
"conditions": [
"Acute Lymphoblastic Leukemia"
],
"interventions": [
"Other: Not applicable - observational study"
],
"location_countries": [
"France",
"United... |
#Study Description
Brief Summary
The study objective is to characterize the shift in the diversity and abundance of the skin microbial community at baseline and in response to Altreno monotherapy as compared to benzoyl peroxide (BPO) 2.5% leave-on gel monotherapy in acne patients.
Detailed Description
With the adve... | #Eligibility Criteria:
Inclusion Criteria:
* A confirmed diagnosis of acne that warrants initiating topical medications.
* Denies use of any prescribed systemic acne treatments in the past 30 days.
* Denies use of any prescribed topical medications in the past 30 days.
* Denies use of any OTC topical acne medications ... | NCT04548349 | {
"brief_title": "Profiling the Skin Microbiome in Response to Altreno in Acne Patients",
"conditions": [
"Acne",
"Healthy"
],
"interventions": [
"Drug: Altreno",
"Drug: Benzoyl peroxide"
],
"location_countries": [
"United States"
],
"nct_id": "NCT04548349",
"official_title": "Prof... |
#Study Description
Brief Summary
The study aim is to assess whether premedication with midazolam prior to surgery affects copeptin concentration in blood.
#Intervention
- DRUG : Midazolam Oral Tablet
- Midazolam Oral tablet
- OTHER : Placebo Oral Tablet
- Glucose 1000mg tablet night before surgery and 60 minute... | #Eligibility Criteria:
Inclusion Criteria:
* Patients scheduled for elective surgery
* Patients with no chronić illness and considered ASA 1 by anesthesiologist
* Patients with mild and controlled chronic illness considered ASA 2 by anesthesiologist
Exclusion Criteria:
* Patient refusal
* Chronic illness requiring i... | NCT03474939 | {
"brief_title": "The Effect of Midazolam Premedication on Copeptine Concentration in Blood",
"conditions": [
"Preanesthetic Medication",
"Copeptin"
],
"interventions": [
"Drug: Midazolam Oral Tablet",
"Other: Placebo Oral Tablet"
],
"location_countries": [
"Poland"
],
"nct_id": "NCT... |
#Study Description
Brief Summary
The study enabled assessment of changes in body mass composition, metabolic syndrome and lipid profile in patients after stroke, following rehabilitation in hospital.
Detailed Description
Stroke is estimated to affect 24-54% of the global population and is one of the leading causes ... | #Eligibility Criteria:
Inclusion criteria:
* Stroke experienced.
* Ability to stand without assistance.
* Ability to walk without aid.
* No impairments in higher mental functions
* Patient's informed, voluntary consent to participate in the study.
Exclusion criteria:
* Lack of patient's consent to participate in the... | NCT03722602 | {
"brief_title": "Body Composition of People After a Stroke",
"conditions": [
"Rehabilitation",
"Stroke",
"Body Composition"
],
"interventions": [
"Other: Standard rehabilitation after stroke"
],
"location_countries": [
"Poland"
],
"nct_id": "NCT03722602",
"official_title": "Effect... |
#Study Description
Brief Summary
A randomized 1:1 crossover trial that intends to demonstrate feasibility and safety of the Automated Insulin Delivery as Adaptive NETwork (AIDANET) system run in a new smaller network version, used in full closed loop (FCL) by adults who have been diagnosed with type 1 diabetes (T1D).... | #Eligibility Criteria:
Inclusion Criteria:
* Age >=18.0 and <=60 years at time of consent
* Clinical diagnosis, based on investigator assessment, of type 1 diabetes for at least one year
* Currently using insulin pump for at least three months; Any pump, either open loop or hybrid closed loop may be used.
* Currently ... | NCT06633965 | {
"brief_title": "Safety and Feasibility Testing of a Smaller Network Version of AIDANET",
"conditions": [
"Type 1 Diabetes"
],
"interventions": [
"Device: AIDANET"
],
"location_countries": [
"United States"
],
"nct_id": "NCT06633965",
"official_title": "Safety and Feasibility Testing of a... |
#Study Description
Brief Summary
This is a double-blind, randomized, placebo-controlled, multicenter study comprised of 3 phases:screening (up to 2 weeks \[Day -15 to Day -2\]), In-Clinic Treatment (Day -1 to Day 2; including double-blind treatment \[Day 1\]), and post-treatment follow-up (7 and 14 days after infusio... | #Eligibility Criteria:
Inclusion Criteria:
* Capable of giving and give signed informed consent
* Weigh >= 50 kg and have a body mass index >= 18 and <= 35
* Diagnosis of recurrent major depressive disorder (MDD) without psychotic features per Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V... | NCT05414422 | {
"brief_title": "A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD",
"conditions": [
"Treatment Resistant Depression"
],
"interventions": [
"Drug: PCN-101",
"Drug: Placebo"
],
"location_countries": [
"Poland",
"Germany",
"United Sta... |
#Study Description
Brief Summary
Childhood cancer survivors are at an increased risk of cardiac toxicity due to prior anti-cancer therapy. However, adherence to cardiac screening in this population remains low. This study aims to assess the feasibility of an mHealth motivational interviewing platform called Computeri... | #Eligibility Criteria:
Inclusion Criteria:
* 18 years or older
* Diagnosed with cancer at age 17 or younger
* 2 or more years after completion of cancer therapy
* Receipt of cardiotoxic therapy (Any dose of anthracycline or 15 Gy chest radiation involving cardiac structures)
* No history of cardiomyopathy
* Have not r... | NCT05923242 | {
"brief_title": "Translating ECHOS2 Into an mHealth Platform",
"conditions": [
"Childhood Cancer",
"Cardiac Toxicity",
"Pediatric Cancer"
],
"interventions": [
"Behavioral: Computerized Intervention Authoring Software (CIAS)"
],
"location_countries": [
"United States"
],
"nct_id": "... |
#Study Description
Brief Summary
When the COVID-19 virus infects a person, it enters the lung epithelial cells of its host and uses its genetic material to replicate.
The pulmonary epithelial cells of a part of the population, known as 'secretors', are capable of expressing the antigens of the 'ABO' system on their ... | #Eligibility Criteria:
Inclusion Criteria:
* COVID19 positive patients admitted within the CHU Brugmann Hospital
Exclusion Criteria:
* None
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT
Accepts Healthy Volunteers:
Yes
| NCT04462627 | {
"brief_title": "Reduction of COVID 19 Transmission to Health Care Professionals",
"conditions": [
"COVID 19"
],
"interventions": [
"Diagnostic Test: Blood group determination",
"Diagnostic Test: Antibody titration",
"Dietary Supplement: Probiotic"
],
"location_countries": [
"Belgium"
... |
#Study Description
Brief Summary
The purpose of this study is to evaluate the safety and efficacy of the BrainPort balance device in improving balance in people with balance deficits due to stroke.
Detailed Description
Following baseline assessments, subjects participate in 5 consecutive days (10 hours) of clinic t... | #Eligibility Criteria:
Inclusion Criteria:
* At least 18 years.
* Diagnosis of stroke for at least 6 months.
* Reached a plateau and been discharged from physical therapy.
* Able to ambulate with or without assistance.
* Ongoing balance problem.
* Able to read and understand the informed consent form, and willing to s... | NCT00567944 | {
"brief_title": "Use of the BrainPort® Balance Device to Improve Balance in Adults With Balance Deficits Due to Stroke",
"conditions": [
"Cerebrovascular Accident"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT00567944",
"official_title": "A Substitute Vesti... |
#Study Description
Brief Summary
Sickle cell anemia (SCA) is a serious blood disease with blood vessel changes leading to brain injury and stroke. Studies show about 11% of patients with SCA will develop obvious stroke before age 20 years, with children less than 10 years of age especially vulnerable. The main object... | #Eligibility Criteria:
Inclusion Criteria for Pre-Hydroxyurea or Pre-Transfusion Therapy Study Participants:
* The diagnosis of HbSS or HbS/ß0-thalassemia
* Age: 8.0 -- <19 years
Inclusion Criteria for Study Participants for Observation:
* The diagnosis of HbSS or HbS/ß0-thalassemia
* Age: 8.0 -- <19 years
Inclusio... | NCT01137721 | {
"brief_title": "State Of The Art Functional Imaging In Sickle Cell Disease",
"conditions": [
"Sickle Cell Anemia"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT01137721",
"official_title": "State Of The Art Functional Imaging In Sickle Cell Disease",
"rec... |
#Study Description
Brief Summary
A multi-center, double-blind, controlled, parallel-designed, prospective trial intended to evaluate the nutritive effects of a partially hydrolyzed cow's milk protein infant formula on infant fussiness.
Detailed Description
A multi-center, double-blind, controlled, parallel-designed... | #Eligibility Criteria:
Inclusion Criteria:
* Primary caregiver has reliable access to the internet and a reliable device (such as a computer, tablet, or smartphone) to access mobile apps and be able to view and complete study questionnaires
* Singleton birth
* 15 to 75 days of age at Visit 1, inclusive (day of birth i... | NCT05245422 | {
"brief_title": "Acceptance of a Partially Hydrolyzed Formula",
"conditions": [
"Fussy Infant (Baby)"
],
"interventions": [
"Other: Infant Formula - Intact protein",
"Other: Infant Formula - Partially hydrolyzed protein"
],
"location_countries": [
"United States"
],
"nct_id": "NCT052454... |
#Study Description
Brief Summary
Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the re... | #Eligibility Criteria:
Inclusion Criteria:
* The following criteria were required for inclusion: being systemically healthy, not smoking, not using antibiotics or systemic corticosteroids within the previous three months, not being pregnant or nursing, not having a chronic inflammatory disease, not receiving periodont... | NCT06091800 | {
"brief_title": "Interleukin 20 and Periodontal Tisuue Destruction",
"conditions": [
"Periodontitis"
],
"interventions": [
"Other: biochemical analysis"
],
"location_countries": [
"Turkey"
],
"nct_id": "NCT06091800",
"official_title": "Determination of Levels of IL-20, TNF-α, IL1β/IL-10, ... |
#Study Description
Brief Summary
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms. Investigators will randomize women to the receipt of CSE or E ... | #Eligibility Criteria:
Inclusion Criteria:
* Nulliparous (no prior childbirth)
* Singleton gestation
* Third trimester
* Healthy pregnancy
* English proficiency (surveys validated in English)
* Planned vaginal delivery
* Planning to use labor epidural analgesia
* Term delivery (>= 37.0 weeks)
Exclusion Criteria:
* S... | NCT03022526 | {
"brief_title": "CSE v. Epidural for Postpartum Depression",
"conditions": [
"Depression, Postpartum",
"Labor Pain"
],
"interventions": [
"Procedure: CSE",
"Procedure: Epidural",
"Drug: Bupivacaine / fentaNYL"
],
"location_countries": [
"United States"
],
"nct_id": "NCT03022526"... |
#Study Description
Brief Summary
AllyQuest is a novel, high impact secondary prevention intervention delivered via mobile phones to improve linkage and engagement in care among newly diagnosed HIV+ young men who have sex with men (YMSM). The features of the intervention aim to target previously identified barriers to... | #Eligibility Criteria:
Inclusion Criteria:
* HIV positive
* Diagnosed in the last 12 months
* Assigned male at birth and self identify as male
* Have had sex with another man in the last twelve months
* Own a smart phone
* Between the ages of 16 <= age <= 24
Exclusion Criteria:
* Assigned female at birth
* Non-Engli... | NCT03090958 | {
"brief_title": "AllyQuest: Engaging HIV+ YMSM in Care Through Social Networking and Gamification",
"conditions": [
"Hiv",
"HIV/AIDS"
],
"interventions": [
"Behavioral: AllyQuest"
],
"location_countries": null,
"nct_id": "NCT03090958",
"official_title": "AllyQuest: Engaging HIV+ YMSM in Car... |
#Study Description
Brief Summary
Testing comedogenicity potential of a device cream on humans.
#Intervention
- DEVICE : Lotion
- Formulated Lotion F# 13451-131 was applied on an occlusive patch and placed on a test site on each subjects back three times a week for four weeks.
- OTHER : Negative Control
- Contro... | #Eligibility Criteria:
Inclusion Criteria:
* Male or female.
* 18 <= age <= 45 old.
* Individuals that are willing to provide written informed consent and are able to read, speak, write, and understand English.
* Individuals who are acne-prone with large pores on the back, or individuals who have a history of acne vul... | NCT03428997 | {
"brief_title": "Human Comedogenicity Test",
"conditions": [
"Comedogenicity"
],
"interventions": [
"Device: Lotion",
"Other: Negative Control"
],
"location_countries": [
"United States"
],
"nct_id": "NCT03428997",
"official_title": "Human Comedogenicity Test",
"recruitment_informat... |
End of preview. Expand in Data Studio
Dataset Card for EC-RAFT Raw ClinicalTrials.gov Dataset
Dataset Summary
This dataset provides a structured version of ClinicalTrials.gov data from , prepared for use in the EC-RAFT framework. It includes structured eligibility criteria (inclusion, exclusion, age, sex), trial descriptions, metadata, interventions, and study design fields.
This dataset was used as the foundation for the paper:
EC-RAFT: Automated Generation of Clinical Trial Eligibility Criteria through Retrieval-Augmented Fine-Tuning
(ACL 2025 Findings).
The EC-RAFT model and training pipeline are available at:
👉 https://github.com/biodatlab/ec-raft
Dataset Structure
Data Instances
Each example is a single clinical trial record with structured metadata and eligibility criteria.
Dataset Splits
| Split | Type | Number of Trials | Total Inclusion Criteria | Total Exclusion Criteria | Mean Inclusion Criteria per Trial (± SD) | Mean Exclusion Criteria per Trial (± SD) |
|---|---|---|---|---|---|---|
| Train | Interventional | 168,429 | 838,948 | 1,256,242 | 4.98 ± 5.11 | 7.46 ± 7.05 |
| Observational | 45,448 | 137,234 | 156,298 | 3.02 ± 2.85 | 3.44 ± 3.68 | |
| Validation | Interventional | 20,928 | 103,910 | 154,896 | 4.97 ± 5.04 | 7.40 ± 7.00 |
| Observational | 5,807 | 17,531 | 20,470 | 3.02 ± 2.77 | 3.53 ± 3.64 | |
| Test | Interventional | 21,129 | 103,982 | 156,212 | 4.92 ± 5.01 | 7.39 ± 7.05 |
| Observational | 5,606 | 16,990 | 19,000 | 3.03 ± 2.99 | 3.39 ± 3.61 |
Citation
If you use this dataset, please cite:
TBD
Contributions
- Nopporn Lekuthai (Mahidol University)
- Nattawit Pewngam (Ravis Technology)
- Supitcha Sokrai (Ravis Technology)
- Titipat Achakulvisut (Mahidol University)
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