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PMC2872605 | Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF | We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent BRAF binding to CRAF, CRAF activation, and MEK–ERK signaling. This does not occur when oncogenic BRAF is inhibited, demonstrating that BRAF inhibit... |
PMC5785775 | Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks | In de novo drug design, computational strategies are used to generate novel molecules with good affinity to the desired biological target. In this work, we show that recurrent neural networks can be trained as generative models for molecular structures, similar to statistical language models in natural language process... |
PMC3629873 | Preliminary evaluation of the CellFinder literature curation pipeline for gene expression in kidney cells and anatomical parts | Biomedical literature curation is the process of automatically and/or manually deriving knowledge from scientific publications and recording it into specialized databases for structured delivery to users. It is a slow, error-prone, complex, costly and, yet, highly important task. Previous experiences have proven that t... |
PMC11334037 | Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors | Gastrointestinal stromal tumors (GISTs) are typical gastrointestinal tract neoplasms. Imatinib is the first-line therapy for GIST patients. Drug resistance limits the long-term effectiveness of imatinib. The regulatory effect of insulin-like growth factor 2 (IGF2) has been confirmed in various cancers and is related to... |
PMC1462997 | "Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene(...TRUNCATED) | "Many novel studies and therapies are possible with the use of human embryonic stem cells (hES cells(...TRUNCATED) |
PMC12217045 | M1 Macrophage‐Derived Extracellular Particles Induce Cell Death in MDA‐MB‐231 Cells | "Triple‐negative breast cancer (TNBC), a leading cause of female mortality worldwide, presents a t(...TRUNCATED) |
PMC10287567 | An integrated cell atlas of the lung in health and disease | "Single-cell technologies have transformed our understanding of human tissues. Yet, studies typicall(...TRUNCATED) |
PMC1315352 | Development of antibodies to human embryonic stem cell antigens | "Using antibodies to specific protein antigens is the method of choice to assign and identify cell l(...TRUNCATED) |
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