options dict | answer stringlengths 1 120 | question stringlengths 188 3.83k | answer_idx stringclasses 7
values |
|---|---|---|---|
{
"A": "105-155",
"B": "120-140",
"C": "125-135",
"D": "128-132",
"E": "129-131",
"F": null,
"G": null,
"H": null,
"I": null
} | 120-140 | Serum LDL-cholesterol concentrations are maeasured in blood samples collected from 25 healthy volunteers. The data follow a normal distribution. The mean and standard deviation for this group are 130 mg/dL and 25 mg/dL, respectively. The standard error of the mean is 5.0. With a 95% confidence level, the true mean for ... | B |
{
"A": "Acute inflammation",
"B": "Fibrinous exudate",
"C": "Fibrous scar",
"D": "Granulation tissue",
"E": "Normal kidney",
"F": null,
"G": null,
"H": null,
"I": null
} | Normal kidney | A 48-year-old man dies suddenly of a cardiac arrhythmia. Six weeks ago, he was resuscitated from a cardiac arrestcaused by coronary artery disease and developed oliguric renal failure. Five weeks ago (1 week after beingresuscitated), his serum urea nitrogen (BUN) concentration was 40 mg/dL, his serum creatinine concent... | E |
{
"A": "5500–9500/mm³",
"B": "<6500/mm3 or >8500/mm³",
"C": "6500–8500/mm³",
"D": "<7500/mm³",
"E": ">9500/mm³",
"F": null,
"G": null,
"H": null,
"I": null
} | <7500/mm³ | In a sample of 100 individuals, the mean leukocyte count is 7500/mm³, with a standard deviation of 1000/mm³. If the leukocyte counts in this population follow a normal (gaussian) distribution, approximately 50% of individuals will have which of the following total leukocyte counts? | D |
{
"A": "Candida albicans",
"B": "Chlamydia trachomatis",
"C": "Herpes simplex virus",
"D": "Human papillomavirus",
"E": "Trichomonas vaginalis ",
"F": null,
"G": null,
"H": null,
"I": null
} | Candida albicans | A 55-year-old woman comes to the clinic because of a 2-month history of increasingly severe vaginal pain and itching during sexual intercourse. She avoids intercourse with her husband because of the symptoms. She has been in a monogamous relationship with her husband for the past 25 years. She has type 2 diabetes melli... | A |
{
"A": "Asthma",
"B": "Bronchiectasis",
"C": "Chronic pulmonary fibrosis",
"D": "Cystic fibrosis",
"E": "Emphysema",
"F": null,
"G": null,
"H": null,
"I": null
} | Emphysema | A 39-year-old man comes to the physician because of a 6-month history of progressive shortness of breath. He has had a cough productive of white sputum for 2 years. He smoked 1 pack of cigarettes daily for 16 years but quit 10 years ago. He is in mild respiratory distress with pursed lips and a barrel chest; he is usin... | E |
{
"A": "Bipolar disorder, manic, with psychotic features",
"B": "Brief psychotic disorder",
"C": "Delusional disorder",
"D": "Psychotic disorder due to general medical condition",
"E": "Schizophrenia",
"F": null,
"G": null,
"H": null,
"I": null
} | Bipolar disorder, manic, with psychotic features | A previously healthy 33-year-old woman is brought to the emergency department by the Secret Service for stalkingthe president of the USA for 2 months. She claims to be married to the president's twin brother and states that thepresident just had his twin kidnapped to avoid competition. She speaks rapidly and is difficu... | A |
{
"A": "Magnesium",
"B": "Vitamin A",
"C": "Vitamin B12 (cobalamin)",
"D": "Vitamin C",
"E": "Zinc",
"F": null,
"G": null,
"H": null,
"I": null
} | Vitamin A | A 53-year-old man comes to the physician because of a dry scaly rash on his body for the past year. He has had a 15-kg (33-lb) weight loss during the past year. He is 178 cm (5 ft 10 in) tall and now weighs 54 kg (120 lb); BMI is 17 kg/m². His stools have a large volume and float. Which of the following nutrient defici... | B |
{
"A": "Positive Predictive Value and Negative Predictive Value increase",
"B": "Positive Predictive Value increase and Negative Predictive Value no change",
"C": "Positive Predictive Value increase and Negative Predictive Value decrease",
"D": "Positive Predictive Value no change and Negative Predictive Value... | Positive Predictive Value decrease and Negative Predictive Value increase | In screening for prostate cancer, the current serum prostate-specific antigen concentration at which biopsy is recommended is 4.1 ng/mL. If the threshold for recommending a biopsy procedure were lowered to 2.0 ng/mL, which of the following changes would occur to the positive and negative predictive values of the test? | G |
{
"A": "Allowing the couple's primary care physician to discuss most of the information with them",
"B": "Allowing the parents time to tell other family members",
"C": "Delaying parental distress until the information is completely disclosed",
"D": "Disclosing the most important information so that it can be un... | Disclosing the most important information so that it can be understood as fully as possible | In informing a couple that their newborn has Down syndrome, there is a specific, relatively limited amount ofinformation that the consulting physician should give immediately. The rest can be discussed at a later time. Whichof the following best explains the purpose of using this approach to disclosure? | D |
{
"A": "Activation of the α1-adrenergic receptor",
"B": "Conversion of testosterone to dihydrotestosterone",
"C": "Conversion of testosterone to estradiol",
"D": "Inhibition of the α1-adrenergic receptor",
"E": "Production of prostate-specific antigen",
"F": null,
"G": null,
"H": null,
"I": null
} | Conversion of testosterone to dihydrotestosterone | A 62-year-old man comes to the physician because of a 6-month history of urinary hesitancy and dribbling afterurination. He has to urinate two to three times nightly. Physical examination shows a diffusely enlarged, firm, andnontender prostate. Which of the following is most likely to have contributed to the developmen... | B |
{
"A": "Decreased hepatic secretion of lecithin",
"B": "Decreased reabsorption of bile salts",
"C": "High ratio of cholesterol to bile acids in bile",
"D": "Infestation with parasites secreting β-glucuronidase",
"E": "Overload of unconjugated bilirubin",
"F": null,
"G": null,
"H": null,
"I": null
} | Overload of unconjugated bilirubin | An 18-year-old woman with sickle cell disease is brought to the emergency department by her parents because of a 2-hour history of severe abdominal pain and nausea. Her parents say that she had a cheeseburger, milk shake, andchocolate bar for lunch. Her temperature is 37°C (98.6°F). Physical examination shows tendernes... | E |
{
"A": "Apo B48",
"B": "Apo C",
"C": "HMG-CoA reductase activity",
"D": "LDL receptor",
"E": "Lipoprotein lipase activity",
"F": null,
"G": null,
"H": null,
"I": null
} | LDL receptor | A 45-year-old man is brought to the emergency department 30 minutes after the sudden onset of crushing chest pain.His father, maternal aunt, and paternal uncle all died of myocardial infarctions under the age of 50 years. Physicalexamination shows tendinous xanthomas on the hands and thickened Achilles tendons. Serum l... | D |
{
"A": "Caspase activation",
"B": "Decreased cytochrome c concentration",
"C": "Decreased intracellular Ca2+ concentration",
"D": "Increased glutathione peroxidase activity",
"E": "Increased lysosomal enzyme activity",
"F": null,
"G": null,
"H": null,
"I": null
} | Caspase activation | An experimental animal is created in which the germinal centers of the reactive lymph nodes show shrinkage of cells,cytoplasmic budding, no adjacent inflammation, and intact plasma membranes. These cellular findings are most likelycaused by which of the following mechanisms? | A |
{
"A": "Greater chance of a Type I error",
"B": "Greater chance of a Type II error",
"C": "Less chance of a Type I error",
"D": "Less chance of a Type II error",
"E": "Impossible to predict",
"F": null,
"G": null,
"H": null,
"I": null
} | Less chance of a Type II error | Investigators conduct a study that evaluates the effect of finasteride on the incidence of prostate cancer in 500 patients.The investigators recruit an additional 1000 patients for the study. Which of the following effects will this have on theresearch study? | D |
{
"A": "Astrocytes",
"B": "Ependymal cells",
"C": "Fibroblasts",
"D": "Microglial cells",
"E": "Oligodendrocytes",
"F": null,
"G": null,
"H": null,
"I": null
} | Astrocytes | A 76-year-old man dies of a massive cerebral infarction shortly after admission to the hospital. During the past 10years, he has had several smaller cerebral infarctions and two transient ischemic attacks. Examination of a cerebralcortex specimen obtained at autopsy shows extensive gliosis. This finding is most likely ... | A |
{
"A": "Calcitriol production by activated macrophages",
"B": "Local resorption of bone by metastases",
"C": "Parathyroid hormone-related peptide secretion",
"D": "Secretion of parathyroid hormone",
"E": "Secretion of thyroid-stimulating hormone",
"F": null,
"G": null,
"H": null,
"I": null
} | Calcitriol production by activated macrophages | A previously healthy 52-year-old woman comes to the physician because of a 2-month history of fatigue, constipation,and frequent urination. Her temperature is 37.1°C (98.8°F), pulse is 80/min, respirations are 14/min, and bloodpressure is 140/90 mm Hg. Diffuse crackles are heard bilaterally. Her serum calcium concentra... | A |
{
"A": "Aromatic L-amino acid decarboxylase",
"B": "Dopamine β-hydroxylase",
"C": "Monoamine oxidase B",
"D": "Phenylethanolamine N-methyltransferase",
"E": "Tyrosine hydroxylase",
"F": null,
"G": null,
"H": null,
"I": null
} | Monoamine oxidase B | A 66-year-old man who was recently diagnosed with Parkinson disease comes to the physician for a follow-upexamination. Carbidopa-levodopa therapy was initiated at the time of diagnosis. The patient tells the physician that hestill has episodes during which he "freezes." He has a clumsy gait, and there is rigidity of hi... | C |
{
"A": "Leiomyomata uteri",
"B": "Perimenopause",
"C": "Pregnancy",
"D": "Sexual intercourse",
"E": null,
"F": null,
"G": null,
"H": null,
"I": null
} | Sexual intercourse | A 46-year-old woman comes to the physician because of a 3-day history of intermittent pain with urination andincreased urinary frequency. She says that she had one similar episode during the past 6 months. She also has hadirregular menses, and her last menstrual period occurred 2 months ago. She has not had fever, naus... | D |
{
"A": "Change in laundry detergent",
"B": "Exposure to chemicals during motorcycle repair",
"C": "Handling pigeons",
"D": "Pesticide exposure",
"E": "Use of latex gloves",
"F": null,
"G": null,
"H": null,
"I": null
} | Use of latex gloves | A 28-year-old man comes to the physician because of a 2-month history of a rash on his wrists and hands. He is afirst-year mortuary science student. He also works on his grandfather's farm each weekend. His hobbies include raisinghoming pigeons and repairing vintage motorcycles. He recently changed to a different type ... | E |
{
"A": "Adenovirus",
"B": "Enterovirus",
"C": "Herpes simplex virus",
"D": "Neisseria meningitidis",
"E": "Streptococcus pneumoniae",
"F": null,
"G": null,
"H": null,
"I": null
} | Enterovirus | A 10-year-old boy is brought to the emergency department in the middle of summer because of fever, headache, andphotophobia. Several of his camp mates have had a similar illness. Physical examination shows mild nuchal rigidity.A lumbar puncture is performed. Laboratory studies show:Serum glucose 90 mg/dLCerebrospinal f... | B |
{
"A": "Carotid Sinus Baroreceptor Activity, Atrial Stretch Receptor Activity, and Vagal Efferent Activity to the Heart increase",
"B": "Carotid Sinus Baroreceptor Activity and Atrial Stretch Receptor Activity increase, while Vagal Efferent Activity to the Heart decrease",
"C": "Carotid Sinus Baroreceptor Activit... | Carotid Sinus Baroreceptor Activity, Atrial Stretch Receptor Activity, and Vagal Efferent Activity to the Heart increase | A healthy 30-year-old woman participates in a study of the relationship between cardiovascular function and posture. Placed in a room with a comfortable temperature (72°F) and humidity (40%), she moves from a standing to a supine position. Which of the following sets of changes is most likely in the reflex control of t... | A |
{
"A": "\"From the size of the folder you brought, it looks like you've had very thorough examinations in the past.\"",
"B": "\"I don't have much experience with chronic fatigue syndrome, but I'm committed to learning as much as I",
"C": "\"I'm not familiar with chronic fatigue syndrome, except that many physicia... | "I don't have much experience with chronic fatigue syndrome, but I'm committed to learning as much as I can about it." | A 31-year-old woman with a 5-year history of fatigue comes to the physician for an initial visit. She has seen fourother physicians for the same condition within the past 6 months, but no abnormalities were found. She gives thephysician a large folder that contains her medical records. She says, "I can barely get out o... | B |
{
"A": "Biliary atresia",
"B": "Crigler-Najjar syndrome, type I",
"C": "Gilbert syndrome",
"D": "Hemolytic disease of the newborn",
"E": "Physiologic jaundice",
"F": null,
"G": null,
"H": null,
"I": null
} | Biliary atresia | A 3-week-old girl delivered at term with no complications is brought to the physician by her mother because of a 1-week history of yellow eyes and skin, tan-colored stools, and dark brown urine. The newborn has been breast-feedingwithout difficulty. She is alert and appears to be in no distress. She is at the 50th perc... | A |
{
"A": "Atherosclerosis",
"B": "Congenital renal artery hypoplasia",
"C": "Fibromuscular dysplasia",
"D": "Takayasu arteritis",
"E": "Temporal arteritis",
"F": null,
"G": null,
"H": null,
"I": null
} | Atherosclerosis | A 65-year-old woman comes to the physician for a follow-up examination after blood pressure measurements were175/105 mm Hg and 185/110 mm Hg 1 and 3 weeks ago, respectively. She has well-controlled type 2 diabetesmellitus. Her blood pressure now is 175/110 mm Hg. Physical examination shows no other abnormalities.Antihy... | A |
{
"A": "Higher LDL concentrations are associated with higher hs-CRP concentrations",
"B": "Higher LDL concentrations are associated with lower hs-CRP concentrations",
"C": "Higher LDL concentrations cause higher hs-CRP concentrations",
"D": "Higher LDL concentrations cause lower hs-CRP concentrations",
"E": n... | Higher LDL concentrations are associated with higher hs-CRP concentrations | Results of a study that examined the impact of risk factors on cardiovascular health are being evaluated. In the study,serum LDL-cholesterol (LDL) concentration is found to have a correlation of 0.6 with serum high-sensitivity C-reactive protein (hs-CRP) concentration. Which of the following statements best describes t... | A |
{
"A": "Erythroid progenitor",
"B": "Hematopoietic stem",
"C": "Lymphatic progenitor",
"D": "Megakaryocyte progenitor",
"E": "Pluripotent stem",
"F": null,
"G": null,
"H": null,
"I": null
} | Hematopoietic stem | A 72-year-old man comes to the physician for a health maintenance examination. He has no personal or family historyof major medical illnesses. He has never smoked cigarettes. Pulse oximetry on room air shows an oxygen saturationof 98%. Physical examination shows plethoric skin and splenomegaly. Laboratory studies show:... | B |
{
"A": "Occupational exposure",
"B": "Substance use",
"C": "Travel",
"D": "Type of home heating",
"E": "Use of over-the-counter medication",
"F": null,
"G": null,
"H": null,
"I": null
} | Type of home heating | A 21-year-old man comes to the emergency department in the winter because of headache, nausea, and dizziness for4 hours. He has not had fever, chills, or shortness of breath. He has no history of major medical illness. He lives in abasement apartment of a three-story house. He smokes 1½ packs of cigarettes daily. Physi... | D |
{
"A": "Inhibition of estrogen synthesis",
"B": "Inhibition of 11β-hydroxylase activity",
"C": "Inhibition of prostaglandin synthesis",
"D": "Stimulation of follicle-stimulating hormone synthesis",
"E": "Stimulation of luteinizing hormone synthesis",
"F": null,
"G": null,
"H": null,
"I": null
} | Inhibition of prostaglandin synthesis | A 25-year-old woman comes to the physician because of a long history of pain with menses. The pain occurs on thefirst day of her 5-day menstrual period and lasts all day. She rates the pain as 10 on a 10-point scale. The mostappropriate initial pharmacotherapy to relieve this patient's pain has which of the following m... | C |
{
"A": "17α-Hydroxyprogesterone deficiency",
"B": "Increased concentration of müllerian-inhibiting substance",
"C": "Maternal androgen exposure",
"D": "Presence of the sex-determining region Y gene",
"E": "5α-Reductase deficiency",
"F": null,
"G": null,
"H": null,
"I": null
} | Maternal androgen exposure | A 3800-g (8-lb 6-oz) newborn is delivered vaginally at 39 weeks' gestation after an uncomplicated pregnancy. Apgar scores are 9 and 9 at 1 and 5 minutes, respectively. The newborn is crying, has pink skin, and appears vigorous. Physical examination shows a vagina and also a structure that appears to be a penis, with th... | C |
{
"A": "Increased enzyme secretion",
"B": "Increased enzyme synthesis",
"C": "Karyolysis",
"D": "Lysis of the endoplasmic reticulum",
"E": "Lysis of the plasma membrane",
"F": "Mitochondrial swelling",
"G": null,
"H": null,
"I": null
} | Lysis of the plasma membrane | A 65-year-old man is admitted to the hospital because of a 12-hour history of chest pain. Physical examination showsno abnormalities. Serum studies show an increased troponin I concentration. The diagnosis of myocardial infarctionis made. It is suspected that this patient's condition deteriorated as a result of ischemi... | E |
{
"A": "(18/1000) – (12/1000)",
"B": "0.85 × (12/1000)",
"C": "0.85 × (18/1000)",
"D": "[0.85 × (18/1000–12/1000)]",
"E": "[(1.2/100) – (1.8/100)]/(1.8/100)",
"F": null,
"G": null,
"H": null,
"I": null
} | (18/1000) – (12/1000) | A randomized clinical trial is conducted to compare wound healing and cosmetic differences between two surgicalprocedures for closing skin wounds following cesarean delivery. A total of 1000 women undergoing cesarean deliveryduring a 6-month period are enrolled in the study, which was 85% of the total number of patient... | A |
{
"A": "Hyperglycemia caused by increased glucose consumption",
"B": "Hyperglycemia caused by increased glycogen metabolism",
"C": "Hyperglycemia caused by insufficient exogenous insulin",
"D": "Hypoglycemia caused by excess exogenous insulin",
"E": "Hypoglycemia caused by excessive renal glucose loss",
"F"... | Hypoglycemia caused by excess exogenous insulin | A 4-year-old girl with type 1 diabetes mellitus is brought to the emergency department by her father because of a 4-hour episode of restlessness, sweating, and confusion that occurred during the night. Yesterday, he allowed her to eatcupcakes and cotton candy at a county fair. At her bedtime that evening, he increased ... | D |
{
"A": "1/100",
"B": "1/400",
"C": "1/1000",
"D": "1/4000",
"E": "1/10,000",
"F": null,
"G": null,
"H": null,
"I": null
} | 1/100 | A male newborn is delivered at term to a 28-year-old primigravid woman. Physical examination shows a broad, flatnose; low-set ears; a receding chin; prominent infraorbital folds; and bilateral abdominal masses. The newborndevelops cyanosis, difficulty breathing, and polyuria and dies 24 hours after birth. At autopsy, e... | A |
{
"A": "Bile salt metabolism",
"B": "Cholesterol metabolism",
"C": "Cytochrome P450 activity",
"D": "Purine metabolism",
"E": "Urea cycle",
"F": null,
"G": null,
"H": null,
"I": null
} | Purine metabolism | A previously healthy 64-year-old man is brought to the emergency department 3 hours after the sudden onset of severeflank pain. He has no history of similar pain or serious illness. He takes no medications. He appears to be in distress.His pulse is 100/min, and blood pressure is 168/92 mm Hg. Physical examination shows... | D |
{
"A": "Decreased absorption",
"B": "Decreased distribution",
"C": "Decreased elimination",
"D": "Increased distribution",
"E": "Increased elimination",
"F": "Increased metabolism",
"G": null,
"H": null,
"I": null
} | Decreased absorption | A 32-year-old woman with hypothyroidism comes to the physician because of a 6-week history of cold intolerance, constipation, and severe fatigue. She also has had a 4.5-kg (10-lb) weight gain during this period. Her current medication is daily levothyroxine. She also started taking calcium carbonate supplements 2 month... | A |
{
"A": "Adjacent to the ventral pancreas",
"B": "Along the lesser curvature of the stomach",
"C": "At the origin of the celiac vessels",
"D": "In a portion of the hepatic diverticulum",
"E": "Within the dorsal mesogastrium",
"F": null,
"G": null,
"H": null,
"I": null
} | Within the dorsal mesogastrium | A 19-year-old man undergoes splenectomy because of crush injuries sustained in a motor vehicle collision. During the operation, two small accessory spleens are seen adjacent to the ruptured spleen. The most likely origin of this patient's congenital anomaly is thickening of an embryologic layer at which of the followin... | E |
{
"A": "Blockade of dopamine receptors",
"B": "Decreased activity of dopamine transporters",
"C": "Enhancement of the effect of postsynaptic γ-aminobutyric acid (GABA)",
"D": "Increased GABA transaminase activity",
"E": "Inhibition of glutamate release",
"F": "Inhibition of serotonin reuptake",
"G": "Open... | Enhancement of the effect of postsynaptic γ-aminobutyric acid (GABA) | A 48-year-old man comes to the physician requesting treatment for alcohol withdrawal. He reports a 30-year history of consuming 6 to 10 beers daily. He has had two citations for driving while intoxicated. He has previously experienced alcohol-associated seizures and withdrawal symptoms. His vital signs are within norma... | C |
{
"A": "Create an exercise regimen for the patient",
"B": "Explore barriers to diet adherence",
"C": "Increase the patient's insulin dosage",
"D": "Increase the patient's metformin dosage",
"E": "Measure the patient's blood glucose concentration",
"F": "Order measurement of the patient's microalbumin concen... | Explore barriers to diet adherence | A 48-year-old woman with type 2 diabetes mellitus comes to the physician for a follow-up examination. Current medications are metformin and once-daily insulin. She travels frequently and works long hours. She says that her meals are usually fast food. She leads a sedentary lifestyle. She often forgets to measure her bl... | B |
{
"A": "Epstein-Barr virus",
"B": "Hepatitis B virus",
"C": "Measles virus",
"D": "Mumps virus",
"E": "Rubella virus",
"F": null,
"G": null,
"H": null,
"I": null
} | Mumps virus | A 19-year-old man who is a college freshman comes to the office because of a 4-day history of tender, swollen glands. He also has a 6-day history of fever, malaise, and decreased appetite. His temperature is 38.7°C (101.7°F). Physical examination shows swelling of the parotid glands. Which of the following infectious a... | D |
{
"A": "Bradykinin",
"B": "Histamine",
"C": "Leukotriene B₄",
"D": "Nitric oxide",
"E": "Prostaglandin E₂",
"F": null,
"G": null,
"H": null,
"I": null
} | Bradykinin | A 38-year-old woman who is a veteran comes to the emergency department because of a 4-hour history of a sensation of tightness in her throat and swelling of her face, lips, and tongue. She has not had itching. During the past 3 weeks, she has had two similar, milder episodes that resolved without treatment within 24 to... | A |
{
"A": "Nondisjunction",
"B": "Recombination",
"C": "Sister chromatid exchange",
"D": "Telomere breakage",
"E": "Transposon insertion",
"F": null,
"G": null,
"H": null,
"I": null
} | Recombination | A 48-year-old woman comes to the physician because of a 2-month history of fatigue and poor appetite; she has had a 3-kg (6.6-lb) weight loss during this period. Abdominal examination shows moderate splenomegaly. Laboratory studies show a leukocyte count of 185,000/mm³ (65% segmented neutrophils with 6% blasts and prom... | B |
{
"A": "Bicarbonate",
"B": "Gastric acid",
"C": "Glucagon",
"D": "Insulin",
"E": "Intrinsic factor",
"F": null,
"G": null,
"H": null,
"I": null
} | Bicarbonate | A 2-year-old boy is brought to the physician because of failure to thrive. He also has had loose, fatty, foul-smelling stools and a cough during the past 2 weeks. He is at the 30th percentile for height and 10th percentile for weight. Physical examination shows no other abnormalities. Laboratory studies show steatorrhe... | A |
{
"A": "Factor VII (proconvertin)",
"B": "Fibrinogen",
"C": "Glycoprotein IIb-IIIa",
"D": "Granule storage pool",
"E": "von Willebrand factor",
"F": null,
"G": null,
"H": null,
"I": null
} | Glycoprotein IIb-IIIa | A 10-year-old boy is brought to the physician because of a 3-week history of nosebleeds and easy bruisability. His older brother has had similar episodes. He is at the 30th percentile for height and weight. Physical examination shows nasal and gingival bleeding and several ecchymoses over the trunk and upper and lower ... | C |
{
"A": "Height of P waves in lead I of the patient's ECG",
"B": "Height of R waves in lead V₁ of the patient's ECG",
"C": "Hematocrit",
"D": "Pulmonary vascular resistance",
"E": "Right ventricular diastolic compliance",
"F": "Right ventricular wall thickness",
"G": null,
"H": null,
"I": null
} | Right ventricular diastolic compliance | A previously healthy 45-year-old woman who works as a park ranger comes to the physician because of a 1-week history of shortness of breath, even at rest. She has lived in the mountains at 10,000 feet above sea level for 2 years; the physician’s office is located at sea level. Her pulse is 85/min, respirations are 18/m... | E |
{
"A": "ATP",
"B": "Folic acid",
"C": "Peptidoglycan",
"D": "Protein",
"E": "RNA",
"F": null,
"G": null,
"H": null,
"I": null
} | RNA | A 25-year-old woman comes to the physician because of a 4-month history of cough and unintentional weight loss. Rhonchi are heard posteriorly over the right upper thorax. A chest x-ray shows an 8-cm cavity in the right upper lobe and hilar lymphadenopathy. Ziehl-Neelsen staining of an induced sputum specimen shows acid... | E |
{
"A": "Coronary",
"B": "Falciform",
"C": "Gastrohepatic",
"D": "Hepatoduodenal",
"E": "Triangular",
"F": null,
"G": null,
"H": null,
"I": null
} | Hepatoduodenal | A 34-year-old man is brought to the emergency department 30 minutes after being hit by a motor vehicle while walking. His temperature is 36°C (96.8°F), pulse is 140/min, respirations are 24/min, and blood pressure is 90/60 mm Hg. During an exploratory laparotomy, a large laceration is found that includes the right and ... | D |
{
"A": "Staphylococcus aureus, contaminant",
"B": "Staphylococcus aureus, pathogen",
"C": "Staphylococcus epidermidis, contaminant",
"D": "Staphylococcus epidermidis, pathogen",
"E": "Streptococcus pneumoniae, contaminant",
"F": "Streptococcus pneumoniae, pathogen",
"G": "Streptococcus sanguis, contaminan... | Staphylococcus epidermidis, contaminant | A 1-month-old boy is brought to the emergency department because of a 1-day history of fever and cough. His temperature is 38.2°C (100.8°F), pulse is 140/min, and respirations are 54/min. Physical examination shows intercostal retractions. Wheezes are heard in all lung fields. A blood culture grows coagulase-negative, ... | C |
{
"A": "20 mg/h",
"B": "100 mg/h",
"C": "0.22 L/h",
"D": "2 L/h",
"E": "22 L/h",
"F": null,
"G": null,
"H": null,
"I": null
} | 2 L/h | A new drug, Drug X, is being investigated to determine its pharmacokinetic properties in humans. A male participant who weighs 85 kg (187 lb) with 50 L of total body water begins treatment with an intravenous infusion of Drug X at the rate of 100 mg/h. This drug is known to distribute in total body water. The plasma co... | D |
{
"A": "Bowman capsule",
"B": "Glomerulus",
"C": "Interstitium",
"D": "Proximal tubule",
"E": "Renal vein",
"F": null,
"G": null,
"H": null,
"I": null
} | Proximal tubule | A 78-year-old woman is admitted to the intensive care unit because of diverticulitis complicated by Escherichia coli sepsis. Treatment with ciprofloxacin is started. Three days later, her serum creatinine concentration has increased from 0.7 mg/dL on admission to 1.3 mg/dL. Urinalysis shows muddy brown casts. The most ... | D |
{
"A": "Aspiration pneumonia",
"B": "Guillain-Barré syndrome",
"C": "Insufficient dose of prednisone",
"D": "Motor neuron disease",
"E": "Pyridostigmine overdose",
"F": null,
"G": null,
"H": null,
"I": null
} | Pyridostigmine overdose | A 34-year-old woman with myasthenia gravis comes to the emergency department because of a 2-day history of increasing weakness, shortness of breath, and abdominal cramping. Current medications are prednisone and pyridostigmine. Her temperature is 37°C (98.6°F), pulse is 45/min, and respirations are 25/min and shallow. ... | E |
{
"A": "High Risk for Early Spontaneous Abortions: high Risk for Liveborn Child With Aneuploidy",
"B": "High Risk for Early Spontaneous Abortions: low Risk for Liveborn Child With Aneuploidy",
"C": "Low Risk for Early Spontaneous Abortions: high Risk for Liveborn Child With Aneuploidy",
"D": "Low Risk for Early... | High Risk for Early Spontaneous Abortions: low Risk for Liveborn Child With Aneuploidy | A 35-year-old woman comes to the office because she has had three first-trimester spontaneous abortions during the past 3 years. Physical examination shows no abnormalities. Laboratory studies show no endocrine abnormalities. Chromosomal analysis shows a paracentric inversion of the long arm of chromosome 1. Which of t... | B |
{
"A": "Analysis of triplet repeat sizes of HTT",
"B": "Full sequencing and rearrangement analysis of APC",
"C": "Full sequencing of HTT",
"D": "Specific testing for the APC frame-shift mutation",
"E": "It is not recommended to do predictive genetic testing on a minor",
"F": null,
"G": null,
"H": null,
... | Specific testing for the APC frame-shift mutation | A 12-year-old boy is brought to the office by his parents for genetic counseling because of a family history of genetic disorders. He has no symptoms or history of major medical illness. The patient’s maternal grandfather died of Huntington disease at the age of 35 years. Genetic testing of the mother showed 19 triplet... | D |
{
"A": "Decreased intracellular metabolism of biogenic amines",
"B": "Decreased monoamine oxidase activity",
"C": "Decreased presynaptic receptor activation",
"D": "Increased intracellular metabolism of biogenic amines",
"E": "Increased presynaptic receptor activation",
"F": "Increased release of biogenic a... | Increased release of biogenic amines | A 25-year-old man comes to the office because of a 4-hour history of irritability, restlessness, tremor, and palpitations. He is a known user of amphetamines. His pulse is 120/min, respirations are 25/min, and blood pressure is 150/100 mm Hg. Physical examination shows no abnormalities. The most likely cause of this pa... | F |
{
"A": "Campylobacter jejuni",
"B": "Escherichia coli",
"C": "Rotavirus",
"D": "Salmonella enterica serovar enteritidis",
"E": "Yersinia pestis",
"F": null,
"G": null,
"H": null,
"I": null
} | Escherichia coli | A 5-year-old girl is brought to the office by her mother because of a 6-hour history of bloody diarrhea. She is interactive and in no acute distress. Her blood pressure is 90/55 mm Hg. Abdominal examination shows normoactive bowel sounds. Stool cultures are obtained, and the patient's mother is advised to give the girl... | B |
{
"A": "Allow the patient's husband to serve as an interpreter",
"B": "Consult the hospital ethics committee",
"C": "Explain to the husband that information cannot be provided until the hospital interpreter arrives in the",
"D": "Use a telephone interpreter service",
"E": null,
"F": null,
"G": null,
"H"... | Use a telephone interpreter service | A 78-year-old woman is admitted to the hospital because of a 1-week history of jaundice. CT scan of the abdomen shows a mass suggestive of pancreatic cancer. Three hours later, the on-call physician enters the patient's room to discuss the prognosis and obtain consent for a biopsy scheduled for the next morning. On ent... | D |
{
"A": "Deficiency of terminal complement",
"B": "Hypogammaglobulinemia",
"C": "Impaired T-lymphocyte function",
"D": "Inhibition of tumor necrosis factor α function",
"E": "Neutropenia",
"F": null,
"G": null,
"H": null,
"I": null
} | Neutropenia | A 4-year-old boy develops fever 3 weeks after being admitted to the hospital for induction chemotherapy for treatment of acute lymphoblastic leukemia. Chemotherapy medications are L-asparaginase, dexamethasone, doxorubicin, and vincristine. His temperature is 38.2°C (100.8°F), pulse is 122/min, and respirations are 24/... | E |
{
"A": "Inferior mesenteric vein",
"B": "Inferior vena cava",
"C": "Left colic vein",
"D": "Middle colic artery",
"E": "Pulmonary vein",
"F": "Superior mesenteric artery",
"G": "Superior vena cava",
"H": null,
"I": null
} | Inferior vena cava | A 65-year-old woman comes to the office for a follow-up examination 1 year after she underwent operative resection of the right colon and chemotherapy for stage III colon cancer. She reports fatigue. Physical examination shows no abnormalities. A staging CT scan of the chest and abdomen shows five new 2- to 3-cm masses... | B |
{
"A": "Dihydrofolate reductase",
"B": "Methionine synthase",
"C": "Pyruvate decarboxylase",
"D": "Thiamine pyrophosphate",
"E": "Thymidylate synthase",
"F": null,
"G": null,
"H": null,
"I": null
} | Dihydrofolate reductase | A 6-year-old boy with acute lymphoblastic leukemia is brought to the office for a follow-up examination. He is receiving high-dose methotrexate therapy. A drug is added to the patient's medication regimen to decrease the toxicity of this therapy to normal cells. The beneficial effect of this new drug on normal cells is... | A |
{
"A": "G protein-linked receptors",
"B": "Ligand-gated ion channels",
"C": "Nuclear receptors",
"D": "Receptor tyrosine kinases",
"E": "σ Receptors",
"F": null,
"G": null,
"H": null,
"I": null
} | Nuclear receptors | A 4082-g (9-lb) male newborn is delivered in the hospital at 40 weeks' gestation to a 28-year-old primigravid woman. Pregnancy and delivery were uncomplicated. Apgar scores were 8 and 9 at 1 and 5 minutes, respectively. Examination of the newborn's tongue shows a small blind pit in the midline located near the intersec... | C |
{
"A": "Cathelicidin-related antimicrobial peptide",
"B": "Lysozyme",
"C": "Major basic protein",
"D": "Myeloperoxidase",
"E": "α-Defensin",
"F": null,
"G": null,
"H": null,
"I": null
} | Major basic protein | An investigator is studying how mice respond to filarial parasitic infections. Mice deficient in a specific protein found in eosinophils (Group X) are compared with wild-type mice (Group Y). Biopsies of lymph nodes from Group X mice show more adult worms than lymph nodes from Group Y mice. Group X mice most likely lack... | C |
{
"A": "Decreased serum bicarbonate concentration",
"B": "Increased hemoglobin concentration",
"C": "Increased total lung capacity",
"D": "Left ventricular hypertrophy",
"E": null,
"F": null,
"G": null,
"H": null,
"I": null
} | Increased hemoglobin concentration | A 50-year-old man comes to the office because of a 2-month history of increasing daytime somnolence. He has obstructive sleep apnea for which he has only intermittently used a continuous positive airway pressure device. He is 170 cm (5 ft 7 in) tall and weighs 181 kg (400 lb); BMI is 63 kg/m2. His temperature is 37°C (... | B |
{
"A": "Downregulated parathyroid hormone synthesis, increased serum calcium, increased Serum 1,25- Dihydroxycholecalciferol ",
"B": "Downregulated parathyroid hormone synthesis, increased serum calcium, decreased Serum 1,25- Dihydroxycholecalciferol",
"C": "Downregulated parathyroid hormone synthesis, decreased ... | Upregulated parathyroid hormone synthesis, decreased serum calcium, decreased Serum 1,25- Dihydroxycholecalciferol | An obese 35-year-old man comes to the office for a follow-up examination. He has chronic kidney disease and was told to keep a record of his meals until this follow-up visit. His daily diet consists of chocolate milk and a peanut butter sandwich for breakfast; pizza and cola for lunch; a chocolate bar as a snack; and a... | F |
{
"A": "Arginine vasoreceptor 2 in the proximal tubular cells",
"B": "K+–H+ exchange in the distal tubule",
"C": "Proximal tubule carbonic anhydrase",
"D": "Urea reabsorption in the medullary collecting ducts",
"E": "Water reabsorption in the ascending loop of Henle",
"F": null,
"G": null,
"H": null,
... | Urea reabsorption in the medullary collecting ducts | A 60-year-old woman is nearing the completion of a half marathon. Because she experiences esophageal regurgitation, she does not drink any liquid during the race. This woman's physical state at the end of the race will most likely activate which of the following renal segments at this time? | D |
{
"A": "Atrial septal defect",
"B": "Coarctation of the aorta",
"C": "Mitral stenosis",
"D": "Persistent truncus arteriosus",
"E": "Transposition of the great arteries",
"F": null,
"G": null,
"H": null,
"I": null
} | Persistent truncus arteriosus | An investigator is studying heart development in an experimental animal model. The animal model is genetically modified so that no cardiac neural crest cells develop. This animal model is most likely to have which of the following cardiac abnormalities? | D |
{
"A": "Gastroduodenal",
"B": "Left gastric",
"C": "Left hepatic",
"D": "Right gastric",
"E": "Right hepatic",
"F": null,
"G": null,
"H": null,
"I": null
} | Right hepatic | A 78-year-old woman undergoes an outpatient laparoscopic cholecystectomy. During the procedure, ligation of the cystic artery is planned. It is most appropriate to ligate this artery at its junction with which of the following arteries? | E |
{
"A": " Epstein-Barr virus infection ",
"B": " Gonococcal pharyngitis ",
"C": " HIV infection ",
"D": " Lymphogranuloma venereum infection ",
"E": " Streptococcal pharyngitis ",
"F": null,
"G": null,
"H": null,
"I": null
} | HIV infection | A 32-year-old man comes to the office because of a 2-week history of fever and throat pain. He is 173 cm (5 ft 8 in) tall and weighs 63 kg (140 lb); BMI is 21 kg/m2. His pulse is 110/min, respirations are 16/min, and blood pressure is 98/68 mm Hg. Physical examination shows scattered 2- to 4-cm lymph nodes in the neck,... | C |
{
"A": "Ask the patient how much he is eating and drinking during the holidays",
"B": "Explain the hazards of untreated reflux in the presence of Barrett esophagus",
"C": "Order an upper endoscopy",
"D": "Refer the patient to a gastroenterologist",
"E": "Switch the omeprazole to pantoprazole",
"F": null,
... | Ask the patient how much he is eating and drinking during the holidays | A 51-year-old man with a 10-year history of gastroesophageal reflux and suspected Barrett esophagus comes to the office because his omeprazole dose "doesn't work around the Christmas holidays." He states that he prides himself on having a large appetite and "holding his liquor" during the holidays. He currently takes t... | A |
{
"A": "Cysteine",
"B": "Glutamine ",
"C": "Methionine ",
"D": "Phenylalanine ",
"E": "Tyrosine ",
"F": null,
"G": null,
"H": null,
"I": null
} | Methionine | A 60-year-old man comes to the office because of weakness, tingling of his hands and feet, irritability, and forgetfulness for 4 months. Physical examination shows pallor, weakness, and spasticity. Deep tendon reflexes are increased. Sensation to vibration is absent in the lower extremities. Laboratory studies show meg... | C |
{
"A": "Coxsackievirus",
"B": "Mumps virus",
"C": "Staphylococcus aureus",
"D": "Staphylococcus epidermidis",
"E": "Viridans streptococcus",
"F": null,
"G": null,
"H": null,
"I": null
} | Coxsackievirus | A 12-year-old girl is brought to the office because of a 2-day history of chest pain. She also had a 3-day history of fever that has since resolved. When she lies down, the pain worsens and she has shortness of breath. Her temperature is 37°C (98.6°F). A friction rub is heard. Which of the following is the most likely ... | A |
{
"A": " Collagen ",
"B": " Double-stranded DNA ",
"C": " Nucleolar protein ",
"D": " Phospholipid ",
"E": " Proteins in neutrophil cytoplasm",
"F": null,
"G": null,
"H": null,
"I": null
} | Collagen | A 32-year-old man comes to the office because of a 1-day history of cough productive of small amounts of blood and a 2-day history of shortness of breath and swelling of his ankles. He also has a 2-week history of progressive fatigue and episodes of dark urine. He has no history of major medical illness and takes no me... | A |
{
"A": "\"Are there any reasons why you might want to quit smoking?\"",
"B": "\"Are you aware that your lung condition is chronic at this point?\"",
"C": "\"I'm sure you don't want your wife to suffer as a result of your smoking.\"",
"D": "\"The majority of your health issues would improve if you quit smoking.\... | "Are there any reasons why you might want to quit smoking?" | A 58-year-old man with chronic obstructive pulmonary disease comes to the clinic with his wife for a follow-up examination. He has smoked one pack of cigarettes daily for 35 years. He has tried to quit smoking twice but was unsuccessful both times. At today’s visit, when the physician asks the patient about smoking ces... | A |
{
"A": "Anterior pituitary gland",
"B": "Bowman capsule",
"C": "Glomerulus",
"D": "Hypophysial portal system",
"E": "Loop of Henle",
"F": "Supraoptic nucleus",
"G": null,
"H": null,
"I": null
} | Supraoptic nucleus | A 26-year-old man comes to the office because of a 1-week history of increased urinary frequency accompanied by excessive thirst. He says he has been urinating hourly. Physical examination shows no abnormalities. Serum chemistry studies are within the reference ranges. Urine osmolality is 50 mOsmol/kg H2O. After admini... | F |
{
"A": "Decreased Fremitus, dull Percussion, decreased breath sounds ",
"B": "Decreased Fremitus, hyperresonant Percussion, decreased breath sounds ",
"C": "Decreased Fremitus, hyperresonant Percussion, dull breath sounds ",
"D": "Increased Fremitus, dull Percussion, bronchial breath sounds ",
"E": "Increased... | Decreased Fremitus, hyperresonant Percussion, decreased breath sounds | A 19-year-old man who is in the US Army is brought to the emergency department 45 minutes after he sustained a knife wound to the right side of his chest during an altercation. He has no history of major medical illness and takes no medications. His temperature is 36.9°C (98.4°F), pulse is 110/min, respirations are 24/... | B |
{
"A": "increased renal blood flow, increased ultrafiltration pressure, decreased glomerular filtration rate",
"B": "increased renal blood flow, decreased ultrafiltration pressure, increased glomerular filtration rate",
"C": "increased renal blood flow, decreased ultrafiltration pressure, decreased glomerular fil... | ↑ renal blood flow, ↓ ultrafiltration pressure, ↓ glomerular filtration rate | A 45-year-old man comes to the office for a follow-up examination 1 month after routine urinalysis showed an increased protein concentration. He has a 15-year history of type 2 diabetes mellitus and a 10-year history of hypertension. Current medications include hydrochlorothiazide, insulin, and metformin. His blood pre... | C |
{
"A": "11β-Hydroxylase",
"B": "21α-Hydroxylase",
"C": "3α-Hydroxysteroid dehydrogenase",
"D": "3β-Hydroxysteroid dehydrogenase",
"E": "5α-Reductase",
"F": "17α-Reductase",
"G": null,
"H": null,
"I": null
} | 21α-Hydroxylase | A 3438-g (7-lb 9-oz) female newborn is delivered in the hospital at term to a 24-year-old primigravid woman after an uncomplicated pregnancy. Apgar scores are 8 and 9 at 1 and 5 minutes, respectively. Examination of the newborn shows ambiguous genitalia. Results of a blood analysis show markedly increased serum concent... | B |
{
"A": "Antithrombin III deficiency",
"B": "Factor V Leiden mutation",
"C": "Glanzmann thrombasthenia",
"D": "Protein C deficiency",
"E": "von Willebrand disease",
"F": null,
"G": null,
"H": null,
"I": null
} | Factor V Leiden mutation | A 27-year-old woman comes to the emergency department because of a 1-hour history of severe shortness of breath. She has just returned from a cross-country flight. She has a history of borderline hypertension. Her temperature is 36.9°C (98.5°F), pulse is 113/min, respirations are 28/min, and blood pressure is 138/85 mm... | B |
{
"A": "Calcium ",
"B": "Chloride ",
"C": "Magnesium ",
"D": "Potassium ",
"E": "Sodium ",
"F": null,
"G": null,
"H": null,
"I": null
} | Potassium | A 17-year-old boy is brought to the clinic for a follow-up examination. He has been evaluated for three episodes of full-body weakness at the ages of 13, 16, and 17 years. Each episode occurred when he lay down after playing in a football scrimmage. The weakness improved spontaneously during the next 6 hours; he was a... | D |
{
"A": "Diet",
"B": "Family illness",
"C": "Recent travel",
"D": "Trauma",
"E": "Unintended weight loss",
"F": null,
"G": null,
"H": null,
"I": null
} | Trauma | A 20-year-old woman is brought to the urgent care center because of a 2-month history of progressive weakness of her arms. She also has a 1-week history of moderate back pain and headache. Her only medication is ibuprofen as needed for pain. Muscle strength is 3/5 in the upper extremities. Sensation to pinprick is decr... | D |
{
"A": "Astrocytes",
"B": "Oligodendrocytes",
"C": "Satellite cells",
"D": "Schwann cells",
"E": "Tanycytes",
"F": null,
"G": null,
"H": null,
"I": null
} | Schwann cells | A 15-year-old girl is brought to the rehabilitation facility for physical therapy. Two months ago, she was involved in a motor vehicle collision in which she sustained a crush injury to the ulnar nerve at the right elbow. Neurologic examination shows severe weakness and atrophy of the intrinsic muscles of the right han... | D |
{
"A": "Neuroblastoma",
"B": "Pheochromocytoma",
"C": "Retinoblastoma",
"D": "Rhabdomyosarcoma",
"E": "Thyroid cancer",
"F": null,
"G": null,
"H": null,
"I": null
} | Rhabdomyosarcoma | A 3-year-old boy is brought to the office because of a 2-day history of bulging of his left eye. He says his eye hurts. He has no history of major medical illness or recent trauma to the area, and he receives no medications. Vital signs are within normal limits. Physical examination shows exophthalmos of the left eye. ... | D |
{
"A": "1 ",
"B": "2 ",
"C": "3 ",
"D": "4 ",
"E": "5 ",
"F": null,
"G": null,
"H": null,
"I": null
} | 2 | An 11-year-old girl is brought to the emergency department by her parents because of a 1-week history of breast enlargement. She has not had pain or nipple discharge. She has asthma treated with inhaled albuterol as needed. She does not smoke cigarettes, drink alcoholic beverages, or use illicit drugs. She is at the 50... | B |
{
"A": "Constipation",
"B": "Cystic fibrosis",
"C": "Hirschsprung disease",
"D": "Hookworm infestation",
"E": "Intussusception",
"F": null,
"G": null,
"H": null,
"I": null
} | Constipation | A 5-year-old boy is brought to the emergency department by his mother because of an episode of bloody stool 3 hours ago. The mother says the stool was hard "like pebbles" and she noted bright red blood on the tissue when the patient cleaned himself. His previous bowel movement was 5 days ago. The patient has no abdomin... | A |
{
"A": "Abnormal bleeding",
"B": "Diet",
"C": "Relationship with her family",
"D": "Respiratory symptoms",
"E": "Urinary symptoms",
"F": null,
"G": null,
"H": null,
"I": null
} | Relationship with her family | An 80-year-old woman is brought to the emergency department (ED) 30 minutes after she fell out of her wheelchair at home. This is the second visit to the ED for a fall during the past 3 months. She lives with her daughter and son-in- law, who say they “do the best we can.” The patient has dementia, Alzheimer type, coro... | C |
{
"A": "Cadherin",
"B": "Intercellular adhesion molecule-1",
"C": "L-selectin",
"D": "MAC-1",
"E": "Very late antigen-4",
"F": null,
"G": null,
"H": null,
"I": null
} | L-selectin | An investigator is studying the impact of glucocorticoids on leukocyte dynamics in an experimental animal model. After dexamethasone administration, the total number of circulating neutrophils increases. Most of the additional neutrophils in circulation are detached; these neutrophils were previously loosely adherent a... | C |
{
"A": "“I am concerned about your memory loss. Let’s discuss how to further evaluate your memory.”",
"B": "“There's no need to worry right now, but let's meet again in 6 months.”",
"C": "“Unfortunately, your memory loss will likely increase significantly during the next 5 years; let’s discuss",
"D": "“Your epi... | “Your examination findings indicate that your memory loss is likely consistent with the normal aging | A 67-year-old man comes to the office because he is concerned about memory loss. He says he sometimes forgets the names of acquaintances he sees while he is out shopping. He also has occasional word-finding difficulty and forgets to buy some items when he goes shopping unless he makes a list. He lives alone and is able... | E |
{
"A": "Erythema multiforme",
"B": "Linear IgA bullous dermatosis",
"C": "Pemphigus vulgaris",
"D": "Staphylococcal scalded skin syndrome",
"E": "Toxic epidermal necrolysis",
"F": null,
"G": null,
"H": null,
"I": null
} | Toxic epidermal necrolysis | A 30-year-old woman comes to the office because of a 4-day history of an increasingly severe, painful rash over her body and in her mouth. The rash began over her trunk area but spread within a day to her face and extremities. Two days before development of the rash, she had flu-like symptoms with muscle aches and fati... | E |
{
"A": " Calcium absorption",
"B": " Calcium excretion",
"C": " Osteoblast proliferation",
"D": " Osteoclast proliferation",
"E": " Phosphorus absorption",
"F": " Phosphorus excretion ",
"G": null,
"H": null,
"I": null
} | Osteoclast proliferation | A 45-year-old woman comes to the office for a follow-up examination 2 weeks after she sustained a vertebral fracture at L1. The fracture occurred spontaneously and there is no history of trauma to the area or other fractures. She gained 27 kg (60 lb) during the 6 months before the fracture occurred. Her only medication... | D |
{
"A": "Exacerbation of infection by Borrelia burgdorferi",
"B": "Infection-mediated sepsis",
"C": "IgE-mediated allergic reaction to doxycycline",
"D": "Release of bacterial products producing acute inflammation",
"E": "Secretion of bacterial endotoxins",
"F": null,
"G": null,
"H": null,
"I": null
} | Release of bacterial products producing acute inflammation | A 25-year-old woman comes to the emergency department because of a 3-hour history of fever, severe headache, light-headedness, dizziness, shaking chills, and muscle aches. Five hours ago, she was diagnosed with Lyme disease and began doxycycline therapy. She has no other history of serious illness and takes no other me... | D |
{
"A": "Hypospadias",
"B": "Limb hypoplasia",
"C": "Neck webbing",
"D": "Short palpebral fissures",
"E": "Spasticity ",
"F": null,
"G": null,
"H": null,
"I": null
} | Short palpebral fissures | A 2-week-old male newborn is brought to the office for a well-child examination. He was delivered following an uncomplicated, spontaneous vaginal delivery at 41 weeks' gestation. The mother has no history of serious illness and did not receive prenatal care. Her only medication is a prenatal vitamin. She has consumed l... | D |
{
"A": "Cytomegalovirus",
"B": "Epstein-Barr virus",
"C": "HIV",
"D": "Human herpesvirus 8",
"E": null,
"F": null,
"G": null,
"H": null,
"I": null
} | Epstein-Barr virus | A 15-year-old boy is brought to the office by his parents to discuss results of a biopsy done 3 days ago for a rapidly enlarging neck mass. He first noted the mass 1 month ago. Two weeks ago, he was evaluated for an episode of prolonged epistaxis and was found to have a right ear effusion, which was treated with amoxic... | B |
{
"A": "BMI",
"B": "Family history",
"C": "Medication use",
"D": "Previous fractures",
"E": "Recent physical activity",
"F": null,
"G": null,
"H": null,
"I": null
} | BMI | A 14-year-old boy is brought to the emergency department by his parents because of a 1-month history of intermittent right knee pain that has worsened during the past day. He rates his current pain as a 6 on a 10-point scale and says that it worsens when he walks and lessens when he sits. During the past 2 weeks, he ha... | A |
{
"A": "\"As the patient, you really should make any decision you feel is best for you.\"",
"B": "\"Before I make recommendations, can you tell me what you understand about your options?\"",
"C": "\"Given the stage of the cancer, I recommend mastectomy.\"",
"D": "\"How important is it to you to keep your breast... | "Before I make recommendations, can you tell me what you understand about your options?" | A 38-year-old woman comes to the clinic to discuss results of a biopsy specimen of a mass in the right breast obtained 1 week ago. She has no history of serious illness and takes no medications. Vital signs are within normal limits. Examination of the right breast shows a well-healing biopsy incision. The remainder of... | B |
{
"A": "Fetal lung/epithelial differentiation",
"B": "Fetal lung/surfactant development",
"C": "Fetal renal hemodynamics",
"D": "Maternal placental perfusion",
"E": "Maternal prostaglandin synthesis",
"F": null,
"G": null,
"H": null,
"I": null
} | Fetal renal hemodynamics | A 36-year-old woman with hypertension comes to the office because she thinks she may be “going through early menopause.” She has not had a menstrual period since her most recent office visit 6 months ago. During this time, she also has been “gaining weight around the middle” despite increased exercise; she has had a 6.... | C |
{
"A": "Activation of mutations of TSH receptors",
"B": "Increased serum thyroglobulin concentration",
"C": "Ischemic injury to the hypothalamus",
"D": "Lymphocytic infiltration of the thyroid",
"E": "Presence of TSH receptor autoantibodies",
"F": null,
"G": null,
"H": null,
"I": null
} | Lymphocytic infiltration of the thyroid | A 25-year-old woman, gravida 1, para 1, comes to the office because of a 2-week history of palpitations and heat intolerance. She delivered her child 3 months ago following an uncomplicated pregnancy and delivery. She is breast- feeding. She has no history of serious illness and takes no medications. She is 163 cm (5 f... | D |
{
"A": "Intravenous vancomycin and cefepime therapy",
"B": "Intravenous vitamin B1 (thiamine) therapy",
"C": "Oral lactulose therapy",
"D": "Oral lorazepam therapy",
"E": null,
"F": null,
"G": null,
"H": null,
"I": null
} | Oral lactulose therapy | A 68-year-old man is brought to the emergency department because of a 2-day history of progressive lethargy and tremors. He has alcoholism and opiate, cocaine, and amphetamine use disorder, but he has abstained from alcohol and illicit substances during the past 2 weeks. He also has alcoholic cirrhosis. His only medica... | C |
{
"A": "CT angiography of the chest",
"B": "Determination of serum angiotensin-converting enzyme activity",
"C": "Measurement of serum IgE concentration",
"D": "Mesenteric angiography",
"E": "Serum antiglomerular basement membrane assay",
"F": "Serum antineutrophil cytoplasmic autoantibody assay",
"G": "S... | Serum antineutrophil cytoplasmic autoantibody assay | A 45-year-old woman comes to the emergency department because of a 3-day history of progressive shortness of breath, cough productive of blood-tinged sputum, and fever. She also has a 3-month history of numbness of her left leg and tingling in her right arm. She has not had chills. She was diagnosed with asthma 6 month... | F |
{
"A": "Overactive bladder",
"B": "Overflow incontinence",
"C": "Stress incontinence",
"D": "Urinary retention",
"E": "Urinary tract infection",
"F": null,
"G": null,
"H": null,
"I": null
} | Urinary retention | An 87-year-old woman, gravida 6, para 6, is brought to the emergency department because of a 24-hour history of severe abdominal pain and an inability to void. She notes that for the past 2 months, she has had difficulty emptying her bladder, especially at the end of the day. Twenty years ago, she underwent mastectomy ... | D |
{
"A": "Atovaquone-proguanil",
"B": "Fluticasone",
"C": "Hepatitis A vaccine",
"D": "Methimazole",
"E": "Omeprazole",
"F": "Yellow fever vaccine",
"G": null,
"H": null,
"I": null
} | Methimazole | A 25-year-old woman is admitted to the hospital because of a 2-day history of fever, dizziness, light-headedness, chills, and shaking. She has hyperthyroidism, gastroesophageal reflux disease, and asthma. Her medications are oral methimazole and omeprazole, and inhaled fluticasone, and she has been on the same dosages ... | D |
{
"A": "Antibiotic therapy",
"B": "Antiemetic therapy",
"C": "CT scan of the chest",
"D": "X-ray of the abdomen",
"E": "Reassurance",
"F": null,
"G": null,
"H": null,
"I": null
} | Antibiotic therapy | A 16-year-old boy is brought to the emergency department because of a 2-day history of fever, nausea, vomiting, headache, chills, and fatigue. He has not had any sick contacts. He underwent splenectomy for traumatic injury at the age of 13 years. He has no other history of serious illness and takes no medications. He a... | A |
{
"A": "Adherence to immunization guidelines",
"B": "Avoidance of eating meals in the campus dining hall",
"C": "Consistent hand washing",
"D": "Isolation of other students on campus with febrile illness",
"E": "Prophylactic antibiotic therapy",
"F": null,
"G": null,
"H": null,
"I": null
} | Adherence to immunization guidelines | A previously healthy 29-year-old woman is admitted to the hospital because of a 1-day history of moderate headache, fever, and lethargy. Two days ago, she underwent wisdom tooth extraction. She takes no medications. She cannot remember her vaccination history. She does not smoke cigarettes, drink alcohol, or use illici... | A |
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