Daily Papers

Despite the stunning ability to generate high-quality images by recent text-to-image models, current approaches often struggle to effectively compose objects with different attributes and relationships into a complex and coherent scene. We propose T2I-CompBench, a comprehensive benchmark for open-world compositional text-to-image generation, consisting of 6,000 compositional text prompts from 3 categories (attribute binding, object relationships, and complex compositions) and 6 sub-categories (color binding, shape binding, texture binding, spatial relationships, non-spatial relationships, and complex compositions). We further propose several evaluation metrics specifically designed to evaluate compositional text-to-image generation. We introduce a new approach, Generative mOdel fine-tuning with Reward-driven Sample selection (GORS), to boost the compositional text-to-image generation abilities of pretrained text-to-image models. Extensive experiments and evaluations are conducted to benchmark previous methods on T2I-CompBench, and to validate the effectiveness of our proposed evaluation metrics and GORS approach. Project page is available at https://karine-h.github.io/T2I-CompBench/.

In this work, we show that text-to-image generative models can be 'inverted' to assess their own text-image understanding capabilities in a completely automated manner. Our method, called SelfEval, uses the generative model to compute the likelihood of real images given text prompts, making the generative model directly applicable to discriminative tasks. Using SelfEval, we repurpose standard datasets created for evaluating multimodal text-image discriminative models to evaluate generative models in a fine-grained manner: assessing their performance on attribute binding, color recognition, counting, shape recognition, spatial understanding. To the best of our knowledge SelfEval is the first automated metric to show a high degree of agreement for measuring text-faithfulness with the gold-standard human evaluations across multiple models and benchmarks. Moreover, SelfEval enables us to evaluate generative models on challenging tasks such as Winoground image-score where they demonstrate competitive performance to discriminative models. We also show severe drawbacks of standard automated metrics such as CLIP-score to measure text faithfulness on benchmarks such as DrawBench, and how SelfEval sidesteps these issues. We hope SelfEval enables easy and reliable automated evaluation for diffusion models.

Deep learning promises to dramatically improve scoring functions for molecular docking, leading to substantial advances in binding pose prediction and virtual screening. To train scoring functions-and to perform molecular docking-one must generate a set of candidate ligand binding poses. Unfortunately, the sampling protocols currently used to generate candidate poses frequently fail to produce any poses close to the correct, experimentally determined pose, unless information about the correct pose is provided. This limits the accuracy of learned scoring functions and molecular docking. Here, we describe two improved protocols for pose sampling: GLOW (auGmented sampLing with sOftened vdW potential) and a novel technique named IVES (IteratiVe Ensemble Sampling). Our benchmarking results demonstrate the effectiveness of our methods in improving the likelihood of sampling accurate poses, especially for binding pockets whose shape changes substantially when different ligands bind. This improvement is observed across both experimentally determined and AlphaFold-generated protein structures. Additionally, we present datasets of candidate ligand poses generated using our methods for each of around 5,000 protein-ligand cross-docking pairs, for training and testing scoring functions. To benefit the research community, we provide these cross-docking datasets and an open-source Python implementation of GLOW and IVES at https://github.com/drorlab/GLOW_IVES .