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Dec 24

Retinex-RAWMamba: Bridging Demosaicing and Denoising for Low-Light RAW Image Enhancement

Low-light image enhancement, particularly in cross-domain tasks such as mapping from the raw domain to the sRGB domain, remains a significant challenge. Many deep learning-based methods have been developed to address this issue and have shown promising results in recent years. However, single-stage methods, which attempt to unify the complex mapping across both domains, leading to limited denoising performance. In contrast, existing two-stage approaches typically overlook the characteristic of demosaicing within the Image Signal Processing (ISP) pipeline, leading to color distortions under varying lighting conditions, especially in low-light scenarios. To address these issues, we propose a novel Mamba-based method customized for low light RAW images, called RAWMamba, to effectively handle raw images with different CFAs. Furthermore, we introduce a Retinex Decomposition Module (RDM) grounded in Retinex prior, which decouples illumination from reflectance to facilitate more effective denoising and automatic non-linear exposure correction, reducing the effect of manual linear illumination enhancement. By bridging demosaicing and denoising, better enhancement for low light RAW images is achieved. Experimental evaluations conducted on public datasets SID and MCR demonstrate that our proposed RAWMamba achieves state-of-the-art performance on cross-domain mapping. The code is available at https://github.com/Cynicarlos/RetinexRawMamba.

  • 6 authors
·
Sep 11, 2024

RedDino: A foundation model for red blood cell analysis

Red blood cells (RBCs) are essential to human health, and their precise morphological analysis is important for diagnosing hematological disorders. Despite the promise of foundation models in medical diagnostics, comprehensive AI solutions for RBC analysis remain scarce. We present RedDino, a self-supervised foundation model designed for RBC image analysis. RedDino uses an RBC-specific adaptation of the DINOv2 self-supervised learning framework and is trained on a curated dataset of 1.25 million RBC images from diverse acquisition modalities and sources. Extensive evaluations show that RedDino outperforms existing state-of-the-art models on RBC shape classification. Through assessments including linear probing and nearest neighbor classification, we confirm its strong feature representations and generalization ability. Our main contributions are: (1) a foundation model tailored for RBC analysis, (2) ablation studies exploring DINOv2 configurations for RBC modeling, and (3) a detailed evaluation of generalization performance. RedDino addresses key challenges in computational hematology by capturing nuanced morphological features, advancing the development of reliable diagnostic tools. The source code and pretrained models for RedDino are available at https://github.com/Snarci/RedDino, and the pretrained models can be downloaded from our Hugging Face collection at https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc

  • 4 authors
·
Aug 11 2

Reprogramming Pretrained Language Models for Antibody Sequence Infilling

Antibodies comprise the most versatile class of binding molecules, with numerous applications in biomedicine. Computational design of antibodies involves generating novel and diverse sequences, while maintaining structural consistency. Unique to antibodies, designing the complementarity-determining region (CDR), which determines the antigen binding affinity and specificity, creates its own unique challenges. Recent deep learning models have shown impressive results, however the limited number of known antibody sequence/structure pairs frequently leads to degraded performance, particularly lacking diversity in the generated sequences. In our work we address this challenge by leveraging Model Reprogramming (MR), which repurposes pretrained models on a source language to adapt to the tasks that are in a different language and have scarce data - where it may be difficult to train a high-performing model from scratch or effectively fine-tune an existing pre-trained model on the specific task. Specifically, we introduce ReprogBert in which a pretrained English language model is repurposed for protein sequence infilling - thus considers cross-language adaptation using less data. Results on antibody design benchmarks show that our model on low-resourced antibody sequence dataset provides highly diverse CDR sequences, up to more than a two-fold increase of diversity over the baselines, without losing structural integrity and naturalness. The generated sequences also demonstrate enhanced antigen binding specificity and virus neutralization ability. Code is available at https://github.com/IBM/ReprogBERT

  • 7 authors
·
Oct 5, 2022